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  • 1
    Electronic Resource
    Electronic Resource
    Defective calcium uptake in keratinocyte cell cultures from vitiliginous skin (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 137-139 
    Details
    ISSN: 1432-069X
    Keywords: Vitiligo ; Calcium ; Free radicals ; Keratinocyte cultures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 45Ca2+ has been used to measure the kinetics for the uptake, efflux, and “steady state” of this regulatory cation in keratinocytes grown from the involved and uninvolved skin of one donor (JM) with vitiligo. Cells grown from uninvolved skin yielded a very rapid uptake and efflux of this isotope before reaching “steady state”. A similar profile has been found for keratinocytes from normal healthy adult controls. However, cells established from vitiliginous skin showed a slow uptake of 45Ca2+ before reaching the same “steady state” as the controls. 45Ca2+ efflux has not been observed in vitiliginous keratinocytes. Furthermore, vitiliginous keratinocytes yielded a higher concentration of extracellular bound 45Ca2+ compared with keratinocytes from uninvolved skin. Since Ca2+ has been found to be an allosteric inhibitor of membrane-associated thioredoxin reductase, this defect in Ca2+ transport may explain the proposed breakdown in free radical defense in vitiligo. These findings may also shed some more light on the etiology of this disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00456842
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Regulation of thioredoxin reductase by calcium in Hermansky-Pudlak syndrome (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 40-44 
    Details
    ISSN: 1432-069X
    Keywords: Hermansky-Pudlak syndrome ; Calcium ; Free radicals ; Keratinocyte cell cultures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cell cultures of keratinocytes, established from four Hermansky-Pudlak, syndrome (HPS) homozygotes yielded low membrane-associated thioredoxin reductase activities compared with normal healthy adult controls. This low activity has been shown to be caused by a special sensitivity of the enzyme to calcium. 45Calcium has been used to compare the kinetics for the transport and bioaccumulation of this regulatory cation in keratinocyte cultures of a kindred with HPS (i.e., one HPS homozygote, one HPS obligate heterozygote, one normal family member, and healthy adult controls). The results show that both HPS-homozygous and-heterozygous cells bind more extracellular calcium than noncarriers of this genetic defect, and HPS homozygous cells appear to have a defective calcium transport system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00424271
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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