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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 20 (1981), S. 87-93 
    ISSN: 1432-0428
    Keywords: Identical twins ; concordance ; discordance ; insulin dependent diabetes ; non-insulin dependent diabetes ; genetics ; aetiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 17 (1979), S. 333-343 
    ISSN: 1432-0428
    Keywords: Genetics ; identical twins ; chlorpropamide alcohol flushing ; retinopathy ; enkephalin ; piqûre ; insulin dependent diabetes ; non-insulin dependent diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin dependent (IDD) and non-insulin dependent diabetes (NIDD) are separate disorders. Twin studies show that IDD cannot be entirely due to genetic causes as concordance is no more than about 50%, but there is some inherited predisposition to it as shown by HLA patterns. NIDD, on the other hand, is predominantly due to genetic causes since identical twins are nearly always concordant. Many cases of NIDD show chlorpropamide alcohol flushing (CPAF), a dominantly inherited feature which may precede the appearance of diabetes and thus act as a genetic marker for this type of diabetes. Diabetics who show chlorpropamide acohol flushing are less likely to develop retinopathy than those who do not. Genetic factors must therefore affect the incidence and severity of diabetic retinopathy. Chlorpropamide alcohol flushing is due to sensitivity to enkephalin. Enkephalin and other opioids affect carbohydrate metabolism and insulin release. It is possible therefore that they act as neurotransmitters and cause NIDD by a sympathetically mediated effect on the liver and pancreas — in other words, that as far as NIDD is concerned Claude Bernard's views on the cause of diabetes may have been right.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1939
    Keywords: Bromus tectorum ; Festuca idahoenis ; Frequency distribution ; Plant populations ; Size hierarchy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The moment skewness coefficient, coefficient of variation and Gini coefficient are contrasted as statistical measures of inequality among members of plant populations. Constructed examples, real data examples, and distributional considerations are used to illustrate pertinent properties of these statistics to assess inequality. All three statistics possess some undesirable properties but these properties are shown to be often unimportant with real data. If the underlying distribution of the variable follows the often assumed two-parameter lognormal model, it is shown that all three statistics are likely to be highly and positively correlated. In contrast, for distributions which are not two-parameter lognormally distributed, and when the distribution is not concentrated near zero, the coefficient of variation and Gini coefficient, which are sensitive to small shifts in the mean, are often of little practical use in ordering the equality of populations. The coefficent of variation is more sensitive to individuals in the right-hand tail of a distribution than is the Gini coefficient. Therefore, the coefficient of variation may often be recommended over the Gini coefficient if a measure of relative precision is selected to assess inequality. The skewness coeficient is suggested when the distribution is either three-parameter lognormally distributed (or close to such), or when a measure of relative precision is not indicated.
    Type of Medium: Electronic Resource
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