ISSN:
1432-072X
Keywords:
Paracoccidioides brasiliensis
;
Fungal dimorphism
;
Polyamines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract Putrescine and spermidine were the only polyamines found inParacoccidioides brasiliensis, a dimorphic fungus pathogenic for humans. Free polyamines (putrescine〉spermidine) increased during the first 24 h of yeast growth, with a second peak at 42 h, and also during the first 12 h of mycelium-to-yeast transition (spermidine〉putrescine). Conjugated and bound polyamines were also quantified. 1,4-Diamino-2-butanone decreased free putrescine and spermidine accumulation by inhibiting the activity of ornithine decarboxylase. The increase in free polyamines corresponds to bud emergence in yeast growth and to the mycelium-to-yeast transition ofP. brasiliensis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01682988
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