ISSN:
0947-3440
Keywords:
Pyrimido[6,1-a]isoquinolin-2-ones
;
Fused-skeleton pyrimidinones
;
Conformational analysis by NMR
;
MM2 calculations
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Stereoisomeric (1R*,3R*)- and (1R*,3S*)-6,7-dimethoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline-1-acetamides 5-8 react with formaldehyde or benzaldehyde to furnish stereoisomeric pyrimido[6,1-a]isoquinolin-2-ones 9-18. The relative configurations and the predominant conformations of the products have been determined by NMR spectroscopy, and for (4S*,6R*,11bR*)-9,10-dimethoxy-6-methyl-4-phenyl-1,3,4,6,7,11b-hexahydropyrimido[6,1a]isoquinolin-2-one (11) by X-ray diffraction.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199719970618
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