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  • 1
    Electronic Resource
    Electronic Resource
    Antagonism between sodium hydroxybutyrate and some effects of aminohydroxyacetic acid (1975)
    Springer
    Bulletin of experimental biology and medicine 79 (1975), S. 542-544 
    Details
    ISSN: 1573-8221
    Keywords: GABA ; aminohydroxyacetic acid ; sodium hydroxybutyrate ; convulsive states
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In agreement with data in the literature, a protective effect of aminohydroxyacetic acid (AHAA) was observed as an inhibitor of 4-aminobutyrate:2-oxoglutarate-aminotransferase (GABA-T) in convulsions induced in mice by thiosemicarbazide (TSC), a glutamate decarboxylase inhibitor. A similar but somewhat weaker action was exhibited by sodium hydroxybutyrate (NaHB). Meanwhile, combined administration of NaHB with AHAA reduced the intensity of its anticonvulsant effect with respect to TSC and reduced the accumulation of GABA in the brain characteristic of the action of AHAA. Competition between AHAA, NaHB, and GABA as structurally closely similar compounds for GABA-T or the GABA-ergic receptor is postulated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00800497
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  • 2
    Electronic Resource
    Electronic Resource
    Role of cholinergic mechanisms in the mechanism of action of bicuculline (1978)
    Springer
    Bulletin of experimental biology and medicine 86 (1978), S. 1048-1050 
    Details
    ISSN: 1573-8221
    Keywords: bicuculline ; cholinergic mechanisms ; GABA ; convulsions ; recovery cycle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The hypothesis of a possible role of cholinergic structures in the mechanism of the action of bicuculline was tested by screening and electrophysiological methods. Neither muscarinic (M-) nor nicotinic (N-) cholinolytics (benactyzine, atropine, aprophen,* and pediphen†) abolished convulsions produced in mice by bicuculline. Meanwhile substances inducing the accumulation of γ-aminobutyric acid (GABA) in the brain, such as aminohydroxyacetic acid (AHAA) and depakine, had a well marked protective action against bicuculline convulsions. The electrophysiological experiments also showed that the M-cholinolytic benactyzine does not abolish the effects of bicuculline. Bicuculline was shown to reduce the depression of the test response in the recovery cycle of the primary response of the rat sensomotor cortex when intervals between stimuli measured 40–125 msec, whereas benactyzine reduced the late facilitation of the test response when intervals between stimuli measured 150–300 msec. No interaction could be found between benactyzine and bicuculline by this test. It was concluded from these results that the effects of bicuculline are produced by blockade of postsynaptic GABA receptors and are not connected with the activity of cholinergic structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799587
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  • 3
    Electronic Resource
    Electronic Resource
    The GABA-ergic mechanism of the effect of diazepam on cortical neurons (1976)
    Springer
    Bulletin of experimental biology and medicine 82 (1976), S. 1343-1346 
    Details
    ISSN: 1573-8221
    Keywords: cerebral cortex ; evoked and spontaneous unit activity ; diazepam ; GABA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effect of diazepam, depakine thiosemicarbazide (TSC), and bicuculline on unit activity of the sensomotor cortex arising spontaneously and evoked by sciatic nerve stimulation was studied in unanesthetized, immobilized albino rats. Diazepam was shown to strengthen the inhibitory effects, i.e., to reduce the frequency of spontaneous discharges and to prolong postactivation depression of unit activity (the inhibitory pause). Depakine which increases the brain GABA concentration, had a similar action. Bicuculline, which blocks GABA-ergic receptors, and TSC, which reduces its concentration, had the opposite action and weakened inhibition. A two-way antagonism also was found between diazepam and bicuculline as regards their effect on unit activity. The results confirm the earlier hypothesis that diazepam can potentiate the effect of GABA on cortical neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799470
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of GABA-ergic agents on the analgesic effect of morphine in rats (1979)
    Springer
    Bulletin of experimental biology and medicine 88 (1979), S. 711-714 
    Details
    ISSN: 1573-8221
    Keywords: GABA ; morphine ; cyclic nucleotides ; opiate receptors ; bicuculline ; thiosemicarbazide ; analgesia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In order to detect possible interaction between GABA and opiates, the effects of GABA-ergic drugs on analgesia induced by morphine were studied. The vocalization response to electrical stimulation of the tail in rats was used as an index of the action of morphine. Thiosemicarbazide, an inhibitor of glutamate decarboxylase, and bicuculline, which blocks GABA-ergic receptors, drugs which, it is suggested, can be considered as a group of GABA-negative compounds, weaken and shorten the effect of morphine. Depakine, an inhibitor of α-ketoglutarate-GABA-transaminase, like GABA itself, given in large doses (GABA-positive effects) strengthens morphine analgesia and prolongs its effect. The possible causes of these relations between GABA and opiates are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00804772
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  • 5
    Electronic Resource
    Electronic Resource
    Role of GABA-ergic structures in the mechanism of action of haloperidol (1980)
    Springer
    Bulletin of experimental biology and medicine 89 (1980), S. 311-314 
    Details
    ISSN: 1573-8221
    Keywords: haloperidol ; tranquilizing effect ; GABA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effect of haloperidol on convulsions induced in mice by bicuculline and thiosemicarbazide and on recovery cycles of the primary sensomotor cortical response in rats was studied. In a dose of 0.3–0.5 mg/kg, giving a tranquilizing effect, haloperidol had a protective action against convulsions induced by blockade of GABA receptors through the action of bicuculline, and potentiated depression of the testing response in the recovery cycle of the primary sensomotor cortical response in rats, i. e., within this dose range haloperidol potentiates GABA effects. With an increase in the dose of haloperidol to 1–2 mg/kg its effectiveness in both tests disappeared. On the basis of these results and data in the literature it is suggested that the postsynaptic GABA-positive effect plays an important role in the mechanism of the tranquilizing action of haloperidol and of other neurotropic agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00834237
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  • 6
    Electronic Resource
    Electronic Resource
    Neuropharmacologic properties of pyracetam derivatives (1982)
    Springer
    Bulletin of experimental biology and medicine 94 (1982), S. 1692-1695 
    Details
    ISSN: 1573-8221
    Keywords: neurotropic agents ; pyracetam ; GABA ; hypoxia ; amnesia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00838912
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  • 7
    Electronic Resource
    Electronic Resource
    Electrophysiological and neuropharmacological analysis of interaction between the systems of excitation and inhibition in the cerebral cortex (1997)
    Springer
    Bulletin of experimental biology and medicine 124 (1997), S. 900-903 
    Details
    ISSN: 1573-8221
    Keywords: GABA ; acetylcholine ; cerebral cortex ; restoration cycles of primary somatosensory response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract GABA- and cholinergic substances selectively affect different phases of the restoration cycle of primary somatosensory response in albino rats. The GABA antagonist bicuculline reduced and the deactivation inhibitor valproic acid enhanced depression of the test response when stimulated at pulse intervals of 60–125 msec. The cholinomimetic arecoline enhanced and the cholinolytic amizylum diminished facilitation of test response at intervals of 150–200 msec. The data suggest a dynamic interaction as well as a competition between GABA- and cholimergic systems in processing the sensory input.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02446997
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