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  • 1
    Electronic Resource
    Electronic Resource
    Delayed Gastric Emptying by Helicobacter pylori Lipopolysaccharide in Conscious Rats (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 90-94 
    Details
    ISSN: 1573-2568
    Keywords: HELICOBACTER PYLORI ; LIPOPOLYSACCHARIDE ; GASTRIC EMPTYING
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study was carried out to investigatethe possibility that lipopolysaccharide deprived fromHelicobacter pylori may alter gastric motility. Toaddress the question, we examined the effect of H. pylori lipopolysaccharide on gastricemptying in conscious rats. Gastric emptying wasevaluated by the phenol red method. Time-course anddose-related effects of intraperitoneal administrationof H. pylori lipopolysaccharide were investigated.Intraperitoneal injection of H. pylorilipopolysaccharide significantly suppressed gastricemptying of a liquid meal in a dose-dependent manner.The inhibitory action of H. pylori lipopolysaccharide wasobserved 2, 4, 8, or 12 hr after the injection. Theseresults suggest for the first time that H. pylorilipopolysaccharide may suppress gastric emptying in along-lasting fashion. It is also suggested that H. pylorimay influence gastric function through its cell wallstructure named lipopolysaccharide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018828105226
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Gastric Emptying in OLETF Rats Not Expressing CCK-A Receptor Gene (1997)
    Springer
    Digestive diseases and sciences 42 (1997), S. 915-919 
    Details
    ISSN: 1573-2568
    Keywords: GASTRIC EMPTYING ; CCK-A RECEPTOR ; OLETF RAT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have very recently demonstrated the lowacidity of gastric juice and the high susceptibility tothe development of gastric ulceration in OtsukaLong-Evans Tokushima Fatty (OLETF) rats not expressing CCK-A receptors. In the present study, gastricemptying in this strain was examined and compared withcontrol Long-Evans Tokushima Otsuka (LETO) rats. Gastricemptying was evaluated by the phenol red method. Gastric emptying 30 and 60 min after a liquidmeal in OLETF rats was significantly delayed compared tothat in control LETO rats. Intraperitoneal injection ofCCK-8 at a dose of 5 μg/kg significantly inhibited gastric emptying in control LETO rats, whereasthe same dose of CCK-8 failed to inhibit gastricemptying in OLETF rats. These results suggest for thefirst time that gastric emptying was suppressed in OLETF rats. We also confirmed with this mutant thatCCK delays gastric emptying through the CCK-Areceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018860313674
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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