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  • GLC  (1)
  • P-glycoprotein  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A new sensitive gas-chromatographic method for the determination of fenfluramine in biological specimens (1972)
    Springer
    European journal of clinical pharmacology 5 (1972), S. 62-64 
    Details
    ISSN: 1432-1041
    Keywords: GLC ; fenfluramine ; norfenfluramine ; blood levels ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A new analytical procedure is described for the determination of fenfluramine and norfenfluramine in biological specimens. Fenfluramine and norfenfluramine are converted to the trichloroacetyl derivatives, separated on a 3% OV 17 — Chromosorb Q glass column and measured by ECD. The rapidity, sensitivity and specificity of the technique fulfil all the requirements for routine clinical use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00560898
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Studies on low-level MDR cells (1993)
    Springer
    Cytotechnology 12 (1993), S. 257-264 
    Details
    ISSN: 1573-0778
    Keywords: low resistance ; MDR ; P-glycoprotein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Acquired or spontaneous resistance is a major clinical problem in the treatment of cancer. Low levels of MDR gene expression or P-glycoprotein have been correlated with a high level of drug resistance in vitro and a poor response to chemotherapy in some tumors. A strong correlation between MDR mRNA, P-glycoprotein levels and degree of drug resistance has not been found in several resistant model tumor cell lines. In some cell lines at low and high level of resistance different mechanisms seem to be involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00744667
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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