ISSN:
1573-2568
Keywords:
JEJUNUM
;
BIOLOGICAL TRANSPORT
;
SURFACTANT
;
GLUCOSE
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Nonionic surfactants are commonly present inmany prepared foods and drug formulations as stabilizingagents. The aim of the current study was to examine theeffect of the common nonionic surfactant Tween-80 on jejunal glucose transport. New Zealand Whiterabbits (800-1200 g) were fasted for 24 hr. Jejunaltissue was stripped and mounted in short-circuitedUssing chambers. Unidirectional 3-O-methyl glucose fluxes were determined during a 15-min basaltransport period and a subsequent 15-min experimentalperiod after the mucosal addition of Tween-80 at finalconcentrations of 0.001%, 0.01%, 0.05%, and 0.1%.Tween-80 at final concentrations of 0.1% and 0.05%significantly increased net 3-O-methyl glucose transportover basal levels. The increase in Jnet wasdue to a significant increase in the absorptive Jm-s flux. Tween-80 at 0.01% and0.001% did not significantly alter net glucose transportalthough Jm-s was significantly increased inthe presence of 0.01% Tween-80. Tween-80, inconcentrations commonly found in prepared foods, enhances theintestinal absorption of glucose.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026660004203
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