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  • oxidation  (4)
  • mineral nutrition  (3)
  • GR 113808  (2)
  • 1
    ISSN: 1432-1912
    Keywords: Key words 5-HT4 receptors ; Guinea-pig distal colon ; Rat oesophagus ; GR 113808 ; SB 204070 ; (S)RS 56532 ; RS 23597
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  5-HT4 receptors in isolated distal colon myenteric plexus of guinea-pig, mediating contraction of longitudinal smooth muscle, have been further characterized by selective agonists and antagonists. The indole agonists, 5-HT and 5-methoxytryptamine (5-MeOT), were full agonists (relative to 5-HT) with potency values (pEC50) of 8.0±0.1 (n=50) and 7.8±0.1(n=12), respectively. 5-HT4 receptor agonists of other structural classes, including benzimidazolones (BIMU 1 and BIMU 8), and benzamides ((S)-zacopride, (R)-zacopride, renzapride, SC 49518) were partial agonists with intrinsic activities less than that of 5-HT. In general, the potencies for these compounds at 5-HT4 receptors in guinea-pig colon were similar to the potencies seen in the rat isolated oesophagus, where 5-HT4 receptors mediate relaxation. GR 113808 {[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl1-methyl-1H-indole-3-carboxylate }, RS 39604 {1-[4-amino-5-chloro-2-(3, 5-dimethoxybenzyl-oxy)phenyl]-3-[1-[2-[(methylsulfonyl)amino] ethyl]-4-piperidinyl]-1-propanone hydrochloride and SB 204070 {(1-n-butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate} antagonized 5-HT responses with pA2 values of 9.1±0.1, 9.0±0.2 and 11.0±0.1, respectively. These affinity values were similar to those obtained at 5-HT4 receptors in isolated rat oesophagus (9.0±0.4, 9.3±0.1 and 10.6±0.1, respectively). Despite these operational similarities between 5-HT4 receptors in guinea-pig colon and rat oesophagus, several novel compounds have revealed important differences between 5-HT4 receptors in the two tissues. For example, the substituted benzoate, RS 23597 {3-(piperidine-1-yl) propyl-4-amino-5-chloro-2-methoxybenzoate hydrochloride, acted as a partial agonist (intrinsic activity 0.5) in guinea-pig colon with a potency of 7.6±0.1 (n=16). In isolated rat oesophagus, however, this compound was a surmountable antagonist (pA2=7.8±0.1) with no intrinsic activity. In contrast, the substituted naphthalimide (S)RS 56532 {(S)-6-amino-5-chloro-2-(1-azabicyclo[2, 2, 2]octan-3-yl)2,3-dihydro-1H-benz[de] isoquinoline-1,3-dione hydrochloride}, was a potent (pEC50=7.9±0.1), efficacious partial agonist (intrinsic activity = 0.8) in the rat oesophagus. However, in guinea-pig colon, it was a surmountable antagonist with an affinity (pKB) of 9.4±0.1. Furthermore, several novel, selective, 5-HT4 compounds also showed opposing patterns of intrinsic activities similar to those described for RS 23597 and (S)RS 56532. It is concluded that these differences are inconsistent with differences in 5-HT4 receptor reserves, and may suggest that 5-HT4 receptors in the guinea-pig colon and the rat oesophagus can be operationally distinguished.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1912
    Keywords: 5-HT4 receptors ; Guinea-pig distal colon ; Rat oesophagus ; GR 113808 ; SB 204070 ; (S)RS 56532 ; RS 23597
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 5-HT4 receptors in isolated distal colon myenteric plexus of guinea-pig, mediating contraction of longitudinal smooth muscle, have been further characterized by selective agonists and antagonists. The indole agonists, 5-HT and 5-methoxytryptamine (5-MeOT), were full agonists (relative to 5-HT) with potency values (pEC50) of 8.0 ± 0.1 (n = 50) and 7.8 ± 0.1 (n = 12), respectively. 5-HT4 receptor agonists of other structural classes, including benzimidazolones (BIMU 1 and BIMU 8), and benzamides ((S)-zacopride, (R)-zacopride, renzapride, SC 49518) were partial agonists with intrinsic activities less than that of 5-HT. In general, the potencies for these compounds at 5-HT4 receptors in guinea-pig colon were similar to the potencies seen in the rat isolated oesophagus, where 5-HT4 receptors mediate relaxation. GR 113808 {[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl1-methyl-1H-indole-3-carboxylat}, RS 39604 {1-[4-amino-5-chloro-2-(3,5-dimethoxybenzyloxy)phenyl]-3-[1-[2-[(methylsulfonyl)amino] ethyl]-4-piperidinyl]-1-propanone hydrochloride and SB 204070 {(1-n-butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate} antagonized 5-HT responses with pA2 values of 9.1 ± 0.1, 9.0 ± 0.2 and 11.0 ± 0.1, respectively. These affinity values were similar to those obtained at 5-HT4 receptors in isolated rat oesophagus (9.0 ± 0.4, 9.3 ± 0.1 and 10.6 ± 0.1, respectively). Despite these operational similarities between 5-HT4 receptors in guinea-pig colon and rat oesophagus, several novel compounds have revealed important differences between 5-HT4 receptors in the two tissues. For example, the substituted benzoate, RS 23597 {3-(piperidine-1-yl) propyl-4-amino-5-chloro-2-methoxybenzoate hydrochloride, acted as a partial agonist (intrinsic activity 0.5) in guinea-pig colon with a potency of 7.6 ± 0.1 (n = 16). In isolated rat oesophagus, however, this compound was a surmountable antagonist (pA2 = 7.8 ± 0.1) with no intrinsic activity. In contrast, the substituted naphthalimide (S)RS 56532 {(S)6-amino-5-chloro-2-(1-azabicyclo[2, 2, 2]octan-3-yl)2,3-dihydro-1H-benz isoquinoline-1,3-dione hydrochloride}, was a potent (pEC50 = 7.9 ± 0.1), efficacious partial agonist (intrinsic activity = 0.8) in the rat oesophagus. However, in guinea-pig colon, it was a surmountable antagonist with an affinity (pKB) of 9.4 ± 0.1. Furthermore, several novel, selective, 5-HT4 compounds also showed opposing patterns of intrinsic activities similar to those described for RS 23597 and (S)RS 56532. It is concluded that these differences are inconsistent with differences in 5-HT4 receptor reserves, and may suggest that 5-HT4 receptors in the guinea-pig colon and the rat oesophagus can be operationally distinguished.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Oxidation of metals 26 (1986), S. 231-252 
    ISSN: 1573-4889
    Keywords: oxidation ; titanium ; thermogravimetry ; microhardness ; modeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The oxidation kinetics of commercial purity Ti-A55 exposed to laboratory air in the 593–760°C temperature range were continuously monitored by thermogravimetric analysis. The oxide thickness was measured by microscopy and the substrate contamination was estimated from microhardness measurements. The microhardness depth profiles were converted to oxygen composition profiles using calibration data. The oxygen diffusion coefficient in alpha-Ti appears to be approximately concentration independent in the 1–10 at. % oxygen range. The combination of an “effective diffusion coefficient” and an “effective solubility” at the oxide-metal interface usefully describes the diffusion process over the entire composition range. A model for the total parabolic oxidation kinetics, accounting for the two individual components, oxide growth and solid solution formation, has been proposed. Diffusion coefficient for oxygen in TiO2 has been estimated as a function of temperature and is found to be about 50 times the value in alpha-Ti. The metallographically prepared cross-sections of the oxidized specimens revealed a “moving boundary” in the substrate, parallel to the oxide-metal interface. This boundary was associated with a specific oxygen level of 5.0±0.5 at.%. It occurred at a distance from the oxide-metal interface which was correlatable with temperature and time of exposure. The diffusion coefficient corresponding to the composition of this moving boundary is in excellent agreement with the effective diffusion coefficient for the substrate contamination.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Oxidation of metals 26 (1986), S. 105-124 
    ISSN: 1573-4889
    Keywords: oxidation ; titanium ; thermogravimetry ; microhardness ; modeling ; mechanical properties ; space shuttle reentry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Ti-6Al-2Sn-4Zr-2Mo titanium alloy is a candidate material for multiwall thermal protection system concepts for advanced space transportation system vehicles. The total oxidation kinetics for this alloy, exposed to laboratory air in the 593–760°C range, were monitored by thermogravimetric analysis. The oxide thickness was measured by microscopy and the substrate contamination was estimated from microhardness measurements. Tensile elongation was determined for selected foil specimens after exposure to simulated space shuttle reentry conditions. The variation of total weight gain with time was found to have two distinct parabolic stages separated by a transient region. This transient was due to a process which involved an increase in the parabolic growth rate constant for the oxide and a simultaneous increase in oxygen solubility at the oxide metal interface. The time dependent increase in oxygen solubility at the interface was from about 7 at. % in stage 1 to about 18 at. % in stage 2. The diffusion coefficient for oxygen in the alloy was determined as a function of temperature using the difference between the total weight gain in stage 1 and the corresponding weight gain due to oxide growth. A model for the total oxidation kinetics, accounting for the two individual components namely oxide growth and solid solution formation, is proposed. The activation energy for the diffusion of oxygen in the alpha-solid solution is shown to be roughly equal to the activation energy for the degradation of tensile elongation for the alloy in the foil gage condition.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Oxidation of metals 37 (1992), S. 111-124 
    ISSN: 1573-4889
    Keywords: oxidation ; titanium aluminide ; oxidation kinetics ; oxidation products
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Static oxidation kinetics of Ti-25Al-10Nb-3V-1Mo (atomic percent) were investigated in air over the temperature range of 650–1000°C using thermogravimetric analysis. The oxidation kinetics were complex at all exposure temperatures and displayed up to two distinct stages of parabolic oxidation. Breakaway oxidation occurred after long exposure times at high temperatures. Oxidation products were determined using x-ray diffraction techniques, electron microprobe analysis, and energy dispersive x-ray analysis. Oxide scale morphology was examined using scanning electron microscopy of the surfaces and cross-sections of oxidation specimens. The oxides during the parabolic stages were compact and multilayered, consisting primarily of TiO2 doped with Nb, a top layer of Al2O3 and a thin bottom layer of TiN. The transition between the first and second parabolic stage is linked to the formation of a TiAl layer at the oxide-metal interface. Porosity also formed in the TiO2 layer during the second stage, causing degradation of the oxide and breakaway oxidation.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Oxidation of metals 42 (1994), S. 451-464 
    ISSN: 1573-4889
    Keywords: oxidation ; titanium aluminide ; air ; oxygen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The oxidation behavior of Ti−14Al−21Nb in air and in oxygen was determined over the temperature range 700 to 1000°C. Weight gains in both atmospheres were measured using thermogravimetric analysis. The resulting oxidation products were identified using X-ray diffraction, and oxide morphology was evaluated using electron microscopy and wavelength-dispersive X-ray analysis. Total weight gains in oxygen were up to four times higher than in air, and a higher percentage of the weight gain in oxygen was due to oxygen dissolution into the metal. Based on metallurgical examination of the oxidized specimens, it was concluded that the lower oxidation weight gains in air are due to the formation of a thin layer of TiN and TiAl at the oxide-metal interface which inhibits the diffusion of oxygen into the metal.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-5036
    Keywords: Glomus fasciculatum ; Glomus intraradices ; Glomus macrocarpum ; mineral nutrition ; soil temperature ; Sorghum bicolor ; uptake of P, K, S, Fe, and Zn ; VAMF ; vesicular-arbuscular mycorrhizal fungi
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Sorghum [Sorghum bicolor (L.) Moench] plants were grown in growth chambers at 20, 25 and 30°C in a low P Typic Argiudoll (3.65 µg P g−1 soil, pH 8.3) inoculated with Glomus fasciculatum, Glomus intraradices, and Glomus macrocarpum to determine effects of vesicular-arbuscular mycorrhizal fungi (VAMF) species on plant growth and mineral nutrient uptake. Sorghum root colonization by VAMF and plant responses to Glomus species were temperature dependent. G. macrocarpum colonized sorghum roots best and enhanced plant growth and mineral uptake considerably more than the other VAMF species, especially at 30°C. G. fasciculatum enhanced shoot growth at 20 and 25°C, and mineral uptake only at 20°C. G. intraradices depressed shoot growth and mineral uptake at 30°C. G. macrocarpum enhanced shoot P, K, and Zn at all temperatures, and Fe at 25 and 30°C above that which could be accounted for by increased biomass. Sorghum plant growth responses to colonization by VAMF species may need to be evaluated at different temperatures to optimize beneficial effects.
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  • 8
    ISSN: 1573-5036
    Keywords: aluminium tolerance ; differential nitrate/ammonium uptake ; mineral nutrition ; plant-induced solution pH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Plant tolerance to Al toxicity has been associated with differential nitrate and ammonium uptake and solution pH changes. Sorghum [Sorghum bicolor (L.) Moench] genotypes with tolerance (SC283) and sensitivity (ICA-Nataima) to Al toxicity were grown with different nitrate/ammonium ratios (39:1, 9:1, and 3:1) at 0 and 300 μM Al to determine genotypic differences in nitrate and ammonium uptake, changes in nutrient solution pH, and relationships of these traits to Al toxicity tolerance in the genotypes. ICA-Nataima had greater reductions in nitrate and ammonium uptake than SC283 when plants were grown with Al, but SC283 had higher nitrate and ICA-Nataima had higher ammonium uptake when plants were grown without Al. Differences in nitrate and ammonium uptake were associated with changes in solution pH; pH decreased as long as ammonium was in solution and increased when ammonium was depleted from solution. Greater changes in solution pH occurred when plants were grown with 39:1 compared to 9:1 and 3:1 nitrate/ammonium ratios. Solution pH values were lower when plants were grown with than without Al. The genotypes maintained their relative differences in Al toxicity tolerance when plants were grown separately or together in the same container with Al and with different nitrate/ammonium ratios.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-5036
    Keywords: Glomus fasciculatum ; Glomus intraradices ; Glomus macrocarpum ; mineral nutrition ; soil temperature ; Sorghum bicolor ; uptake of P, K, S, Fe, and Zn ; VAMF ; vesicular-arbuscular mycorrhizal fungi
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Sorghum [Sorghum bicolor (L.) Moench] plants were grown in growth chambers at 20, 25 and 30°C in a low P Typic Argiudoll (3.65 µg P g-1 soil, pH 8.3) inoculated withGlomus fasciculatum, Glomus intraradices, andGlomus macrocarpum to determine effects of vesicular-arbuscular mycorrhizal fungi (VAMF) species on plant growth and mineral nutrient uptake. Sorghum root colonization by VAMF and plant responses toGlomus species were temperature dependent.G. macrocarpum colonized sorghum roots best and enhanced plant growth and mineral uptake considerably more than the other VAMF species, especially at 30°C.G. fasciculatum enhanced shoot growth at 20 and 25°C, and mineral uptake only at 20°C.G. intraradices depressed shoot growth and mineral uptake at 30°C.G. macrocarpum enhanced shoot P, K, and Zn at all temperatures, and Fe at 25 and 30°C above that which could be accounted for by increased biomass. Sorghum plant growth responses to colonization by VAMF species may need to be evaluated at different temperatures to optimize beneficial effects.
    Type of Medium: Electronic Resource
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