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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of epidemiology 14 (1998), S. 775-781 
    ISSN: 1573-7284
    Keywords: High blood lead ; Risk factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: Environmental and occupational lead pollution is a common problem in both developing and industrialized countries. The purpose of this study is to evaluate the risk factors for high blood lead levels among the general population in Taiwan. Methods: After multi-stage sampling, we randomly selected 2803 subjects (1471 males and 1332 females) for this study. Univariate and multivariate logistic regression analyses were conducted to evaluate the risk of high blood lead. To control for differences in age and gender, all analyses were with age-adjusted and gender-stratified. Results: Among males, the mean age is 46 years (15 to 85 years), mean and median blood lead levels is 7.3 and 6.3μg/dl, respectively. Among females, the mean age is 43 years (15 to 84 years), mean and median blood lead level is 5.7 and 4.8μg/dl, respectively. Among males, the history of herbal drug use, drinking water from well or spring sources, and occupational lead exposure are significantly different between relatively high and normal blood lead level subjects. The history of occupational lead exposure, history of herbal drug use, and well or spring sources of drinking water are the major risk factors for high blood lead with odds ratio of 4.62 (95% CI: 2.82–7.55), 3.09 (95% CI: 1.60–5.97), 2.06 (95% CI: 1.13–3.76), and 2.37 (95% CI: 1.39–4.04), respectively. Among females, these characteristics remain important except the sources of drinking water. The history of herbal drug use and occupational lead exposure become the major risk factors for high blood lead with odds ratio of 2.94 (95% CI: 1.26–6.88) and 7.72 (95% CI: 3.51–16.99), respectively. In multivariate logistic regression analyses, we find that the risk factors for high blood lead in both genders include a history of herbal drug use and occupational lead exposure. Among males, the drinking water sources and factories in the neighboring areas are also significant factors for high blood lead. Conclusions: For the goal of reducing prevalence of high blood lead by the year 2000, the improvement and monitoring of the working environment, the careful attention to herbal drug use and the lead-free drinking water sources should be executed as thoroughly as possible to reduce the probability of lead pollution.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of comparative physiology 170 (2000), S. 497-504 
    ISSN: 1432-136X
    Keywords: Key words Anion exchange ; AE1 ; Red blood cells ; Lamprey ; Respiration ; AbbreviationsA carbonic anhydrase activity ; CA carbonic anhydrase ; DIDS 4,4′ diisothiocyanatostilbene-2,2′ disulphonic acid ; GTC-AP guanidium isothiocyanate-acid phenol ; IgGs type G immunoglobins ; P red blood cell HCO−3 permeability ; PCR polymerase chain reaction ; rbc(s) red blood cell(s)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The purpose of the present study was to examine the distribution of the anion exchange protein in the sea lamprey. Southern blots showed that genomic DNA of juvenile lampreys possesses several regions that are similar to segments of the AE gene from other vertebrates. However, physiological experiments examining rapid anion fluxes across the red blood cell (rbc) membrane and molecular experiments examining mRNA transcript levels both indicated that the anion exchange protein is absent in sea lamprey rbcs. In contrast, lamprey kidney, skeletal muscle, liver and heart tissue all appeared to possess mRNA transcripts for an AE protein. Further evidence for the presence of an AE protein in kidney tissue was obtained from Western blots. In order to evaluate the impact of the apparent rbc anion exchange limitations, the bicarbonate permeability of lamprey rbcs was also evaluated using mass spectrometry. The bicarbonate permeability of the lamprey rbc membrane was an order of magnitude lower than that of trout rbcs. Taken together, these results indicate that the gene for the AE protein is indeed present in lampreys, but it is not expressed in the rbc. Moreover, the process of CO2 transport in lamprey probably does not involve bicarbonate transport across the rbc membrane.
    Type of Medium: Electronic Resource
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