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  • 1
    ISSN: 1432-1920
    Keywords: Key words Multiple sclerosis ; High-dose contrast-enhanced magnetic resonance imaging ; Gadolinium-DTPA ; Gadolinium-HP-DO3A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Contrast-enhanced MRI is effective for assessing disease activity in multiple sclerosis (MS) and may provide an outcome measure for testing the efficacy of treatment in clinical trials. To compare the sensitivity of high-dose gadolinium-HP-DO3A with that of a standard dose of gadolinium-DTPA, we studied 16 patients with relapsing-remitting MS in the acute phase of the disease. Each underwent two MRI examinations within at most 48 h. The initial MRI study was with a standard dose of gadolinium-DTPA (0.1 mmol/kg), and the second one an experimental dose of gadolinium-HP-DO3A (0.3 mmol/kg). No adverse effects were attributed to the contrast media. The high-dose study revealed more enhancing lesions than the standard-dose study (56 vs 38). This difference was found to be more relevant for infratentorial and small lesions. Furthermore, with the higher dose, there was a marked qualitative improvement in the visibility and delineation of the lesions.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 18 (1997), S. 163-166 
    ISSN: 1590-3478
    Keywords: Marburg's disease ; Multiple sclerosis ; Neuroimaging ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Descriviamo il decorso clinico, la terapia e i quadri di risonanza magnetica durante un periodo di quattro anni di una paziente affetta da sclerosi multipla acuta tipo Marburg, trattata con steroidi e mannitolo, che sopravvisse al primo attacco. Sebbene il decorso clinico era simile ad una forma remittente di sclerosi multipla, il nostro caso si caratterizzava per la necessità di una protratta terapia steroidea e per la tendenza delle lesioni presenti alla risonanza magnetica di risolversi completamente.
    Notes: Abstract We describe the clinical course, treatment and magnetic resonance findings during a four-year follow-up of a patient with acute multiple sclerosis of the Marburg type, treated with steroid and mannitol therapy, who survived the first bout. Although the course of the disease was clinically indistinguishable from relapsing-remitting multiple sclerosis, our case was characterized by peculiar features. These included the need for protracted steroid therapy and the remarkable tendency of MRI lesions to resolve completely.
    Type of Medium: Electronic Resource
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