ISSN:
1432-1432
Keywords:
Gallus domesticus
;
Vitellogenin gene
;
Allelic polymorphism
;
Insertion-deletion model
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary An allele giving rise to a polymorphism within the 3′ part of the chicken vitellogenin gene was cloned, sequenced, and compared to the previously cloned allele. The polymorphism is formed by a perfect copy of 343 bp from intron 32 in tandem array with a perfect copy of 244 bp from intron 33; this 587-bp element is inserted in a head-to-tail arrangement in intron 33. We propose a mechanism in which an unequal crossing-over resulted in a vitellogenin gene with two exons 33, one of which was subsequently deleted. Thus, intron 33 was enlarged by the tandem repeats without affecting the protein-encoding sequence of the gene. At the boundaries of the repeated elements, two short direct repeats are found that resemble the recombination signals of immunoglobulin genes. They may have had a key role in the formation of the new allele.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02102475
Permalink
