ISSN:
1612-1112
Keywords:
Gas chromatography
;
Headspace sampling
;
GC theory
;
Influence of sample volume
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The role of the volume of the sample and the sample vial in equilibrium headspace-gas chromatography is discussed. A new term, thesample phase fraction (ΦS) is introduced. It is shown that if the value of ΦS is kept constant, the vial's volume has no influence on the “sensitivity” of the headspace analysis (which is proportional to the concentration of the analyte in the headspace). In a given headspace sampling system, concentration of the compound of interest in the headspace (c G * ) at equilibrium is related to the value of ΦS: a higher ΦS will increase c G * . However, the influence is important only in the case of low distribution coefficients: in the case of higher distribution coefficients this influence is negligible. This conclusion is also true for small changes in the sample volume in duplicate analyses: exact reproducibility of the sample volume is important only in the case of low distribution coefficient values.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02262458
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