Digitale Medien
Springer
International archives of occupational and environmental health
37 (1976), S. 47-55
ISSN:
1432-1246
Schlagwort(e):
Phenylglyoxylic acid
;
Gaschromatography
;
Diazomethane derivatization of phenylglyoxylic acid
;
Styrene metabolites
;
Urinalysis of styrene metabolites
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary The derivatization of phenylglyoxylic acid (PGA), a urinary styrene metabolite, gives with diazomethane under ordinary reaction conditions secondary products as expected from the behaviour of other α-keto acids. Thus reproducible quantitative analysis becomes difficult. It is shown that by proper selection of reaction conditions (low temperature, short reaction time) these secondary transformations can be inhibited and exclusive derivatization to the methylester is obtained. A quantitative determination of urinary PGA can be based on this derivatization procedure. However, this method is not considered suitable for routine monitoring due to the delicate reaction conditions necessary. The results are discussed with reference to a recently published procedure based on an unknown derivative of PGA.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00409363
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