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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 414 (1989), S. 558-563 
    ISSN: 1432-2013
    Keywords: Gastric motility ; Human stomach ; Isolated smooth muscle ; Motilin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of motilin on gastrointestinal muscles show great variations in different organs and different species. For a precise regional differentiation, we recorded the mechanical activity of longitudinal and circular strips from fundus, corpus and antrum and of circular preparations from the inner and outer layer of the pyloric sphincter and from the duodenum (20 human stomachs). Motilin produced excitatory effects on the mechanical activity of the circular muscle strips from all regions of the human stomach including the pylorus. The effects on longitudinal preparations and on duodenal strips were weak. The most striking effect was an increase of phasic activity (amplitude) in circular antrum preparations, which exceeded the acetylcholine- and bombesin-induced activity. In pylorus preparations, a strong stimulation of phasic activity was observed with a transition to tonic activity in the inner layer of the pyloric ring at high motilin concentrations. The motilin-induced activity of the pyloric preparations was greater than the acetylcholine-induced contractions and even exceeded the bombesin-induced responses in the outer pylorus. The responses of the muscle strips of the proximal stomach (fundus and corpus) were weaker and did not exceed the acetylcholine-induced activity. All effects remained unaltered by atropine and tetrodotoxin application. The study confirms that motilin can interact directly with the smooth muscle of human stomach.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-2451
    Keywords: Spleen ; Autologous replantation ; Milz ; Autologe Replantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 41 Patienten, bei denen wegen einer traumatischen Milzruptur eine Splenektomie (n = 21) oder eine autologe Replantation von Milzgewebe (n = 20) durchgeführt worden war, stellten sich einer Nachuntersuchung.Ergebnisse: 1. Nach autologer Replantation läßt sich Milzgewebe szintigraphisch nachweisen. z. Bei der traumatischen Milzruptur ist die Splenosisincidenz sehr hoch. 3. Replantiertes Milzgewebe und Splenosis gewährleisten eine ausreichende Clearancefunktion. 4. Durch den Wegfall der Speicherfunktion der Milz erklärt sich eine Erhöhung der B-Lymphocyten und T-Suppressorzellen im peripheren Blut. 5. Die Replantation von Milzgewebe ist eine Alternative zur Milzerhaltung bei schweren Milzverletzungen.
    Notes: Summary A follow-up examination was performed on 41 patients who had had a traumatic rupture of the spleen (autologous replantation,n = 20; splenectomy,n = 21). In all replantation cases spleen tissue was demonstrated scintigraphically. After traumatic ruptures of the spleen, the incidence of splenosis was very high. There was good clearance function in all replantation and splenosis cases. The lack of the spleen's storage function is responsible for elevated B-lymphocyte and T-suppressor-cell levels in peripheral blood. In severe traumatic ruptures, the replantation of splenic tissue is an alternative procedure for preserving the spleen.
    Type of Medium: Electronic Resource
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