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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 267 (1970), S. 170-176 
    ISSN: 1432-1912
    Keywords: Chicken ; Acid Secretion ; Histamine ; Gastrin ; Carbachol ; Huhn ; Säuresekretion ; Histamin ; Gastrin ; Carbachol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The effect of histamine, carbachol, pentagastrin and gastrin extracts of different organs (glandular stomach, gizzard, duodenum) on gastric acid secretion was investigated in unanaesthetized chickens with a gastric fistula. 2. On a molar basis, pentagastrin was three times as potent as carbachol and 12 times as potent as histamine. The dose of pentagastrin required for stimulation of gastric secretion in chickens was very much higher than in mammals. 3. Extracts from the glandular stomach, the gizzard and the duodenum were free from acid secretion stimulating activity. 4. It was concluded that gastric acid secretion in chickens is controlled by a mechanism other than gastrin.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 259 (1968), S. 419-426 
    ISSN: 1432-1912
    Keywords: Cats ; Vagus ; Gastrin ; Gastric Secretion ; Katzen ; Gastrin ; Vagus ; Magensekretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Die Wirkung des gastrin-analogen Tetrapeptidamids Try.Met.Asp.Phe-NH2 und von elektrischen Vagusreizen auf die Magensekretion von anaesthesierten Katzen mit einer Magenfistel wurde untersucht. 2. Das Tetrapeptid verursachte in Dosen von 0,1–3,2 μg/min i.v. nur eine Sekretion von pepsinarmem Magensaft. 3. Auf elektrischen Vagusreiz wurden große Mengen Magensaft und Pepsin sezerniert. 4. Bei den Katzen mit gekreuztem Kreislauf wurden mit dem Magensaft der gereizten Tiere große Mengen Pepsin ausgeschieden, während der Magensaft der nicht gereizten Tiere nur geringe Mengen Pepsin enthielt. 5. Aus den Versuchen wurde geschlossen, daß durch Vagusreizung Gastrin freigesetzt wird, welches als zirkulierendes Hormon die Säuresekretion stimuliert, und daß die Pepsin-Sekretion durch das bei Vagusreizung freigesetzte Acetylcholin verursacht wird.
    Notes: Summary 1. The effect was studied of the gastrin-analogue tetrapeptide amide Try.Met.Asp.Phe-NH2 and electrical vagus stimulation on gastric secretion in anaesthetized gastric fistula cats. 2. The tetrapeptide in doses of 0.1–3.2 μg/min i.v. stimulated the secretion of gastric juice containing only small amounts of pepsin. 3. Electrical vagus stimulation provoked the secretion of large amounts of gastric juice and pepsin. 4. In pairs of cross circulated cats the gastric juice of the vagus stimulated animals contained much pepsin, the gastric juice of the not stimulated animals did not. 5. It was concluded from these results that gastrin was released by vagal excitation and stimulated as a circulating hormone acid secretion and that pepsin secretion was stimulated by a vagal release of acetylcholine.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 265 (1970), S. 301-309 
    ISSN: 1432-1912
    Keywords: Chicken ; Gastrointestinal Tract ; Histamine ; Histidine Decarboxylase ; Gastrin ; Huhn ; Gastrointestinaltrakt ; Histamin ; Histidin-decarboxylase ; Gastrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The histamine, histidine decarboxylase and gastrin content of the oesophagus, crop, glandular stomach, gizzard and duodenum was determined in chickens. 2. Only minute amounts of histamine were found in the oesophagus (0.8 μg/g) and crop (0.5 μg/g). In the glandular stomach (7.7 μg/g), however, the gizzard (4.8 μg/g) and the duodenum (12.9 μg/g) the histamine content was considerably higher. 3. Measurable amounts of the specific histidine decarboxylase activity were found only in the glandular stomach (25.3 nMole newly formed histamine/g · hr−1). 4. In none of the organs investigated, could any gastrin activity be definitely detected. 5. From the experiments it was concluded that gastric acid secretion in chickens may be controlled by systems other than gastrin. The role of histamine in this process is uncertain.
    Type of Medium: Electronic Resource
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