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  • Intestinal metaplasia  (2)
  • Gastrocarcinogenesis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Intestinal metaplasia and adenocarcinoma induced in the stomach of rats by N-propyl-N′-nitro-N-nitrosoguanidine (1979)
    Springer
    Journal of cancer research and clinical oncology 94 (1979), S. 201-206 
    Details
    ISSN: 1432-1335
    Keywords: Intestinal metaplasia ; Gastric carcinoma N-Propyl-N′-nitro-N-nitrosoguanidine ; Wistar rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary PNNG, the propyl derivative of MNNG, was administered to Wistar rats at a concentration of 59.5 μg/ml in the drinking water for 4, 8, and 12 months and the rats were killed in the 15th month. Intestinal metaplasia was induced in the glandular stomachs of 25%, 75%, and 83% of the rats treated with PNNG for 4, 8, and 12 months, respectively. Metaplastic glands were found in the pyloric region, especially near the pyloric ring. These glands contained goblet cells and columnar cells with striated borders. No tumors were found in the stomach of rats after 4-months treatment, but adenomas were found after 8-months treatment, and both adenomas and adenocarcinomas after 12-months treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422498
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Promoting action of croton oil on gastrocarcinogenesis by N-methyl-N′-nitro-N-nitrosoguanidine in rats (1979)
    Springer
    Journal of cancer research and clinical oncology 93 (1979), S. 323-327 
    Details
    ISSN: 1432-1335
    Keywords: Croton oil ; Tumor promotion ; Gastrocarcinogenesis ; Wistar rat ; Crotonöls ; Tumor-Promotion ; Magencarcinogenese ; Wistar-Ratte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die tumorfördernde Wirkung des Crotonöls für die Magencarcinogenese mit MNNG wurde an männlichen Wistar-Ratten untersucht. Bei fünf von 10 Ratten wurden Magencarcinome beobachtet, wobei zuerst während drei Monaten 83 μg/ml MNNG und dann 0.02% Crotonöl, gelöst in 0,5% Tween 60, neun Monate lang verabreicht wurden. Bei Ratten, die drei Monate lang mit MNNG und danach neun Monate lang mit Tween 60 allein behandelt wurden, sind keine Magencarcinome beobachtet worden. Das Auftreten von Magencarcinomen in diesen zwei Gruppen war demnach signifikant unterschiedlich (p〈0.05). Bei Ratten, denen nur Crotonöl mit Tween 60 verabreicht wurde, sind keine Geschwülste beobachtet worden.
    Notes: Summary The promoting effect of croton oil on gastrocarcinogenesis by MNNG was examined in male Wistar rats. Gastric carcinomas were found in five of 10 rats given 83 μg/ml MNNG for three months and then 0.02% croton oil with 0.5% Tween 60 as solvent for nine months. No gastric carcinomas were found in rats given MNNG for three months and then Tween 60 only for nine months. The incidence of gastric carcinomas in these two groups was significantly different (p〈0.05). No tumors were found in rats given only croton oil with Tween 60.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00964588
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Sequential studies on the histopathogenesis of gastric carcinoma in rats by a weak gastric carcinogen, N-propyl-N′-nitro-N-nitrosoguanidine (1980)
    Springer
    Journal of cancer research and clinical oncology 98 (1980), S. 153-163 
    Details
    ISSN: 1432-1335
    Keywords: Gastric carcinoma ; Intestinal metaplasia ; N-Propyl-N′-nitro-N-nitrosoguanidine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sequential studies were made on the histopathologic changes in the glandular stomach of rats induced by a weak carcinogen, N-propyl-N′-nitro-N-nitrosoguanidine (PNNG). Fiftyfour rats were given 100 μg/ml of PNNG in their drinking water for 44 weeks, and then normal tap water until the end of the experiment. Rats were killed at intervals between week 1 and week 88. No marked atrophy or ulceration of the mucosa was found between week 1 and the end of the experiment. Focal intestinal metaplasia was found in week 19 and its incidence increased during the experiment. Adenocarcinoma in situ with extreme cellular atypia was found in mucosa with a normal appearance in week 67. An adenocarcinoma invading the submucosa was found in week 69, and one invading the serosa in week 88. All these pathological lesions were found on the anal side of the pyloric region. No pathologic changes were found in the fundic region. The sequential changes of the mucosa of the glandular stomach induced by this weak gastric carcinogen, PNNG, were very different from those induced by the potent gastric carcinogen, N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). Gastric carcinoma induced by PNNG seems to be more similar to human gastric cancer than that induced by MNNG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405959
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    Paper (German National Licenses)
    Fulltext
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