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Effects of a calcium antagonist (nifedipine) on cats in liveE. coli bacteriemic shock (1988)

Bosson, S. ; Fält, K. ; Haglund, U.

Springer

Research in experimental medicine 188 (1988), S. 357-365

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ISSN: 1433-8580

Keywords: Nifedipine ; E. coli ; Shock ; Gastrointestinal ; Mucosal injury

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The effects of a calcium antagonist, nifedipine, on cardiovascular reactions and on gastrointestinal mucosal integrity was studied in a standardized feline bacteriemic model. Nifedipine pretreatment delayed the development of cardiovascular derangement and reduced the severity of the intestinal but not the gastric mucosal injury. The effect on the intestinal mucosa could be due to the delayed development of hypotensive shock but also to a protective effect on the superficial mucosal cells.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01851204

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