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  • Gastroschisis  (2)
  • Non-ribosomal peptide synthesis  (2)
  • [abr] APRT; adenine phosphoribosyltransferase  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Methotrexate decreases thymidine kinase activity
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 187 (1992), S. 522-528 
    Details
    ISSN: 0006-291X
    Keywords: [abr] APRT; adenine phosphoribosyltransferase ; [abr] AZT; azidothymidine, zidovudine ; [abr] DH; dehydrogenase ; [abr] GPRT; guanine phosphoribosyltransferase ; [abr] IC"5"0; dose required for 50% decrease in activity ; [abr] MTX; methotrexate ; [abr] TdR; thymidine ; [abr] dTMP; thymidylate ; [abr] i.p.; intraperitoneally ; [abr] s.c.; subcutaneously ; [abr] t"1"/"2; the time required for 50% decrease in activity
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(05)81525-6
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Methotrexate decreases thymidine kinase activity
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 187 (1992), S. 522-528 
    Details
    ISSN: 0006-291X
    Keywords: [abr] APRT; adenine phosphoribosyltransferase ; [abr] AZT; azidothymidine, zidovudine ; [abr] DH; dehydrogenase ; [abr] GPRT; guanine phosphoribosyltransferase ; [abr] IC"5"0; dose required for 50% decrease in activity ; [abr] MTX; methotrexate ; [abr] TdR; thymidine ; [abr] dTMP; thymidylate ; [abr] i.p.; intraperitoneally ; [abr] s.c.; subcutaneously ; [abr] t"1"/"2; the time required for 50% decrease in activity
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(05)81525-6
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Intraoperative vascular assessment for estimation of risk in primary closure of omphalocele and gastroschisis (1996)
    Springer
    Pediatric surgery international 11 (1996), S. 86-90 
    Details
    ISSN: 1437-9813
    Keywords: Gastroschisis ; Omphalocele ; Ultrasonography ; Intraoperative colour-coded sonography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Surgical repair of anterior abdominal wall defects is often complicated by a discrepancy between the eviscerated organs and the intra-abdominal space available. Primary closure of the abdominal wall may result in increased intra-abdominal pressure and consecutive circulatory impairment. We report the results of a retrospective and consecutive prospective study evaluating the influence of different witameters on mortality and morbidity in children with gastroschitis and omphalocele. Both studies demonstrated that real-time sonographic investigations, intraoperative Doppler duplex sonography, and colour-coded Doppler sonography provide the oppurtunity to collect objective intraoperative data. Our data indicate that intraoperative vascular assessment facilitates the discrimination between infants who benefit from primary closure and those in whom a staged repair is the treatment of choice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00183732
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Prenatal diagnosis and management of gastroschisis and omphalocele (1996)
    Springer
    Pediatric surgery international 11 (1996), S. 67-71 
    Details
    ISSN: 1437-9813
    Keywords: Gastroschisis ; Omphalocele ; Prenatal diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Prenatal diagnosis of gastroschisis (GS) and omphalocele (OC) has allowed improved antenatal and perinatal management. It was the aim of this study to compare prenatal findings and assess fetal outcome. Twenty-four fetus with GS and 33 with OC were diagnosed prenatally. Maternal serum alpha-protein (MSAFP), sonographic (US), and perinatal data were analyzed. The average maternal age for GS was younger than for OC (24 vs. 30 years). The median MSAFP values were 7.7 multiples of median for GS and 3.6 for OC. The initial US diagnosis was made at 22 weeks for GS and at 19 weeks for OC. A pathological karyotype was observed in 4% of the fetuses with GS and 33% with OC. The mortality of fetuses with OC was twice as high as that of those with GS. Accurate prenatal diagnosis of GS and OC as well as their differentiation are of crucial importance for both counselling of the parents and the resulting antenatal consequences, and provide the basis for optimal interdisciplinary co-operation at a perinatal tertiary-care center.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00183728
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame (1994)
    Springer
    Current genetics 26 (1994), S. 120-125 
    Details
    ISSN: 1432-0983
    Keywords: Domain structure ; N-methyltransferase ; Non-ribosomal peptide synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Cyclosporin A, a potent and clinically-important immunosuppressive drug (SandimmunR), is synthesized from its precursor amino acids by cyclosporin synthetase, a single multi-functional enzyme. In this study we report the cloning of the corresponding coding region of this synthetase. It contains an open reading frame of 45.8 kb which encodes a peptide with a calculated Mr of 1 689 243. The predicted gene product contains 11 aminoacid-activating domains that are very similar to one another and to the domains of other peptide synthetases. Seven of these domains harbour N-methyltransferase functions. This is the largest genomic ORF described so far.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313798
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Disruption of the cyclosporin synthetase gene of Tolypocladium niveum (1994)
    Springer
    Current genetics 26 (1994), S. 461-467 
    Details
    ISSN: 1432-0983
    Keywords: Cyclosporin ; Non-ribosomal peptide synthesis ; Tolypocladium niveum ; Transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Cyclosporin A is a potent and clinically-important immunosuppressive drug (SandimmunR). It is produced by the fungus Tolypocladium niveum. A transformation system for T. niveum ATCC34921 based on hygromycin selection was established. In order to obtain a T. niveum promoter, the cyclophilin gene was isolated using the Neurospora crassa gene as probe. A plasmid vector was constructed in which the promoter region of the T. niveum cyclophilin gene was fused to a bacterial hygromycin phosphotransferase gene. Protoplasts were transformed with this plasmid and hygromycin-resistant transformants were isolated. Using this transformation system, mutants of T. niveum with disrupted versions of the cyclosporin synthetase gene (simA) were engineered by DNA-mediated transformation. Disruption of the gene resulted in loss of the ability to produce cyclosporins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309935
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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