ISSN:
1573-2568
Keywords:
gastrointestinal blood flow
;
gastric motility
;
cold water immersion restraint stress
;
iodo[14C]antipyrine autoradiography
;
hyperemia
;
convolution
;
Gaussian functions
;
gastric ulcers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Cold water immersion restraint (CWIR) is associated with gastric hypercontractility and gastric corpus erosions in the rat. Because the gastric blood flow response to CWIR has not been well defined, we performed the following study. Rats were implanted with force transducers, subjected to CWIR for 2 hr, and then blood flow was determined by the iodo[14C]antipyrine autoradiographic (IAP) technique. When compared to control animals, the CWIR-treated animals displayed foci of gastric corpus hyperemia with a marked and significant increase in blood flow in all layers of the gastric corpus. There was approximately a 100% increase in the mucosa and a 50% increase in the muscularis externa. The hyperemia was not uniform, but rather alternated every 2.1±0.2 mm with regions of low blood flow. Blood flow in the antrum and duodenum was unaffected by CWIR. We conclude that CWIR is associated with alternating regions of high and low blood flow only in the gastric corpus. Reduction of corpus mucosal blood flow might be due to the powerful gastric contractions associated with CWIR.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01296072
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