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  • Gender difference  (1)
  • Parkinson's disease  (1)
  • Plasma renin activity  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Psychopharmacology 70 (1980), S. 313-315 
    ISSN: 1432-2072
    Schlagwort(e): Bromocriptine ; Dopaminergic mechanisms ; Plasma renin activity ; Blood pressure ; Extrapyramidal symptoms
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A single oral intake of 10 mg of Bromocriptine can modify both plasma renin activity (PRA) and arterial blood pressure (BP). The changes in both variables depend on the integrity of the central dopaminergic systems. The parkinsonians whose extrapyramidal symptoms are markedly improved by l-Dopa in association with a decarboxylase inhibitor (IDC) and the untreated parkinsonians are the only patients whose PRA and BP are lowered 1 h after Bromocriptine ingestion. The results obtained in the l-dopainduced dyskinetic parkinsonians are similar to those obtained in the group of l-Dopa-resistant patients. This points to the paradoxical hypothesis of dopaminergic hyposensitivity in the dyskinetic patients. In spite of the absence of correlation between PRA and BP, it is possible that lowering of BP by Bromocriptine is linked to the parallel decrease of PRA. An increase of the BP may be obtained in the dyskinetic and l-Dopa-resistant groups. These data point to a possible involvement of central dopaminergic systems in some aspects of hypertension.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-2072
    Schlagwort(e): Plasmatic renin activity ; Parkinson's disease ; l-Dopa ; Arterial blood pressure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Plasmatic renin activity (PRA) was studied in patients receiving l-dopa, together with a decarboxylase inhibitor, at rest times and after periods of physical exertion. Although we can superimpose the results from untreated Parkinson's disease patients on those of the control group, the results are inversed in stabilized patients (lowered PRA) and dyskinetic patients (increased PRA). There is a definite correlation between the increase in PRA and intensity of the dyskinesia. Dosage is the only other factor differentiating the two groups of Parkinsonians treated. The figures relative to arterial pressure are studied in the various groups.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1439-6327
    Schlagwort(e): Key words Glucose ingestion ; Prolonged exercise ; Gender difference ; Glucose tolerance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract To test glucose tolerance during exercise, the effects of oral glucose ingestion (0.5 g · kg−1) on plasma glucose and hormonal responses (insulin, catecholamines) were investigated in 11 women [mean (SEM) age 21.6 (1.3) years] and 10 men [22.0 (0.3) years] during cycle ergometer exercise (30 min at 60% maximum oxygen consumption, V˙O2max). The two groups exhibited similar V˙O2max values, when expressed per kg of lean body mass. Venous blood samples (5 ml) were withdrawn immediately before the exercise, during the exercise (at 3, 5, 10, 15 and 30 min) and at the 30th min of the recovery period. Glucose was ingested orally between the 2nd and the 3rd min of the exercise. As compared to men, plasma glucose concentrations were lower in women during exercise (P 〈 0.05 at 3, 15 and 30 min) and at the 30th min of the recovery period (P 〈 0.001), while plasma insulin concentrations were higher in women during exercise (P 〈 0.05 at 3, 15 and 30 min). The ratio of the area under the curve for glucose over the area under the curve for insulin was lower in women during exercise (P 〈 0.0002). A linear relationship between glucose and insulin concentrations was found only for women during exercise (r = 0.615, P 〈 0.0001). No gender difference was observed for the catecholamine concentration during exercise. In conclusion, this study postulates that an oral glucose load given at the onset of a prolonged and moderate exercise bout induced lesser plasma glucose and greater insulin concentrations in women as compared to men. These data argue in favour of a greater glucose tolerance in women during exercise.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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