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  • 1
    Electronic Resource
    Electronic Resource
    In vivo transcriptional pattern in theinfC operon ofBacillus stearotbermophilus (1991)
    Springer
    Molecular genetics and genomics 227 (1991), S. 60-64 
    Details
    ISSN: 1617-4623
    Keywords: Translational initiation ; AUU initiation triplet ; Gene regulation ; Transcriptional signals ; Expression of thermophilic proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary By Northern blot and primer extension analyses it was shown that inBacillus stearothermophilus the genesinfC, rpmI andrplT constitute a single transcriptional unit; the promoter and the transcriptional start-point used in vivo were identified and the half-life of the transcript (1.2 min) was determined. No indication of multiple initiation sites nor of differential stability of different regions of the transcript was found. The results suggest thatEscherichia coli andB. stearothermophilus have a different pattern of transcription around theinfC gene cluster and that differential translational efficiency within theinfC-rpmI-rplT transcriptional unit accounts for the different levels of 1173, L35 and L20 expression. The rare AUU initiation codon is the only strictly conserved element of the several peculiar transcriptional and translational features found inE. coli infC. Upon changing this codon to AUG, we found a ca. 30-fold increased expression ofB. stearothermophilus infC, which is similar to that previously found withE. coli infC (i.e. 40-fold), and provided evidence that regulation ofinfC expression through its rare AUU initiation codon might be a general phenomenon in bacteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00260707
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Role of octreotide in the treatment of external pancreatic pure fistulas: a single-institution prospective experience (2000)
    Springer
    Langenbeck's archives of surgery 385 (2000), S. 10-13 
    Details
    ISSN: 1435-2451
    Keywords: Key words External pancreatic fistulas ; Octreotide ; Pancreatic cancer ; Pancreatic surgery ; Pancreatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Introduction: Octreotide was studied in the treatment of pure external pancreatic fistulas. Methods: Eighteen cases (12 males, 6 females) were prospectively observed. Six patients (four after radical surgery for periampullary cancer, one endocrine tumor enucleation and one pancreojejunostomy in chronic pancreatitis) were treated as outpatients with octreotide alone because of low basal fistula output (mean±SD: 96.6±27.4 cc/24 h). Twelve (five radical surgery for cancer, five surgery for severe pancreatitis, one enucleation and one pancreojejunostomy) were treated as inpatients with octreotide plus total parenteral nutrition because of the high output (mean±SD: 448.4±248.2 cc/24 h). Results: Ten of the 12 high-output fistulas healed in 27.8±27.7 days, whereas all low-output fistulas healed in 12.1±6.6 days. Conclusion: Octreotide appears useful in the treatment of external pancreatic fistulas. For optimal results to be achieved, there must be no local infection and no mechanical or anatomical obstacles to the free flow of juice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004230050003
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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