Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Gene technology  (1)
  • Leukotriene  (1)
  • Mercapturic acid pathway  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Transport und Entgiftung: Grundlagen, Ansätze und Perspektiven für die Erforschung der Blut-Hirn-SchrankeDie in diesem Aufsatz verwendeten Fachbegriffe werden im Anhang 1 erläutert. (1997)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 109 (1997), S. 24-42 
    Details
    ISSN: 0044-8249
    Keywords: Enzymkatalyse ; Leukotriene ; Mercaptursäureweg ; Metabolismus ; Xenobiotika ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Blut-Hirn-Schranke (BHS), die in den Hirnkapillaren lokalisiert ist, hält als anatomische Barriere die Homöostase im Gehirn aufrecht. Neben den morphologischen Besonderheiten wurde eine Vielzahl spezifischer Proteine und Transportsysteme beschrieben, die die Barrierenfunktion vervollständigen, gleichzeitig aber auch die selektive Versorgung des Gehirns mit Substanzen aus dem Blut gewährleisten. Sie sind unter anderem aus pharmakologischer Sicht interessant. Erst in den letzten Jahren wurde erkannt, daß die Blut-Hirn-Schranke auch der aktiven Entgiftung (also der Metabolisierung und damit letztendlich der Abwehr neurotoxischer Verbindungen) dient. Wichtig für das Verständnis dieser Prozesse ist die Kenntnis der Grundlagen von Entgiftungsreaktionen und -stoffwechselwegen in exkretorischen Organen, die hier kurz beschrieben werden. Durch die Aufklärung dieser Mechanismen im Gehirn wird das Verständnis der Blut-Hirn-Schranke und ihrer vielschichtigen Schutzfunktionen wesentlich erweitert. Außerdem wird deutlich, daß bei diesen Entgiftungswegen Metabolite mit neurotoxischem oder (wie im Falle der Leukotriene) BHS-schädigendem Potential erst entstehen können. Am Beispiel des Mercaptursäureweges wird hier beschrieben, wie über den Nachweis repräsentativer Enzyme die Funktionen der Zelltypen und Markerproteine der Blut-Hirn-Schranke festgestellt werden können.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19971090105
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Synthetic Gene Fragments in Genetic Engineering - The Renaissance of Chemistry in Molecular BiologyBased on an introductory lecture delivered by J. E. Davies at the EMBO-Workshop “Prospects of Automation in Gene Synthesis” March 27, 1982 in Darmstadt (see also [100]). (1983)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 22 (1983), S. 13-31 
    Details
    ISSN: 0570-0833
    Keywords: Gene technology ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Chemistry and biology paved the way for a new scientific discipline, molecular genetics. The breathtaking progress in deciphering the genetic machinery of a living being within the last 20 years may be attributed mainly to the experimental skill and ingenuity of molecular biologists. Chemists lost interest in the investigation of biological problems. The advances in genetic engineering exemplify the new demands chemists are confronted with in contemporary science. Following a short introduction on the genetics of bacteria, the articles deals with the molecular basis of gene cloning, which is subdivided into in vitro recombination of nucleic acids and in vivo transformation of cells. Next, the criteria for the selection of passenger DNA, vectors, and host cells are discussed. Recombination and transformation are easy-to-learn experimental techniques, whereas the search for the positive clone requires detailed knowledge of microbiology and the ability to handle of a battery of modern biochemical techniques. Finally, the automated chemical synthesis of gene fragments serves to demonstrate that chemistry is starting to make its comeback into molecular biology.
    Additional Material: 22 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.198300131
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Transport and Detoxication: Principles, Approaches, and Perspectives for Research on the Blood - Brain BarrierThe technical terms used in this review are explained in Appendix 1. (1997)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 36 (1997), S. 24-41 
    Details
    ISSN: 0570-0833
    Keywords: enzyme catalysis leukotrienes ; mercapturic acid pathway ; metabolism ; xenobiotics ; Enzyme catalysis ; Leukotrienes ; Mercapturic acid pathway ; Metabolism ; Xenobiotics ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The blood-brain barrier is an anatomical constraint that maintains homeostasis within the brain and consists of uniquely structured brain capillaries. In addition to these morphological features, a number of specific proteins and transport systems (which are relevant to pharmaceutical applications) can be described that complement barrier functions and ensure a selective supply of substances from the blood to the brain. The additional role of the blood-brain barrier as a site of active detoxication by metabolizing and thus defending against neurotoxic substances has only become apparent in the past few years. Fundamental to understanding these processes are the principles of detoxication reactions and metabolic pathways of excretory organs, which will be described briefly here. The confirmation of these mechanisms in the brain enhances understanding of the complex protective functions of the blood-brain barrier. Evidently, these detoxication pathways simultaneously produce metabolites with neurotoxic or, in case of leukotriene, blood-brain barrier damaging potential. Finally, a detailed description of the mercapturic acid pathway of detoxication will be used to illustrate how evidence of representative enzymes can be used to distinguish definite functions of particular cell types and marker proteins of the blood-brain barrier.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.199700241
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...