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  • Polymer and Materials Science  (33)
  • General Chemistry  (10)
  • Moclobemide  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Initial monoamine oxidase-A inhibition by moclobemide does not predict the therapeutic response in patients with major depression A double blind, randomized study (1996)
    Springer
    Psychopharmacology 127 (1996), S. 370-376 
    Details
    ISSN: 1432-2072
    Keywords: Key words Monoamine oxidase-A inhibition ; Treatment outcome ; DHPG ; L-dopa ; DOPAC ; HVA ; 5-HIAA ; Moclobemide ; Depressive patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It is generally accepted that the clinical efficacy of monoamine oxidase inhibitors (MAOI) is related to inhibition of this enzyme. In order to evaluate the predictive ability of monoamine oxidase-A inhibition for therapeutic efficacy, the start of treatment effects of moclobemide, a selective, reversible monoamine oxidase-A inhibitor, on plasma concentrations of monoamines and monoamine metabolites were determined. The plasma levels of 3,4-dihydroxyphenylglycol (DHPG, deaminated metabolite of noradrenaline), 5-hydroxyindoleacetic acid (5-HIAA, deaminated metabolite of serotonin), 3,4-dihydroxyphenylacetic acid and homovanillic acid (DOPAC and HVA, deaminated metabolites of dopamine), L-dihydroxyphenylalanine (L-dopa) and noradrenaline were investigated and related to treatment outcome. This was a randomized double blind parallel group study in 47 patients with criteria of major depression according to DSM III R. Moclobemide 300 mg/day, 450 mg/day or 600 mg/day was administered continuously for 6 weeks. Plasma concentrations of monoamine metabolites and monoamines were determined just before treatment by moclobemide, 4 h after the first dose, 24 h after the first dose, before the first dose on day 7, and 4 h after the first dose on day 7. Each moclobemide dose improved depression as measured by MADRS (Montgomery-Asberg Depression Rating scale) but there was no difference between the three doses. Moclobemide dose-dependently reduced plasma concentration of DHPG, L-dopa and HVA. No dose-dependent treatment effect was observed for plasma 5-HIAA, noradrenaline and DOPAC. The clinical outcome as defined by the final MADRS score was not related to any start of treatment changes in plasma monoamine metabolites reflecting inhibition of MAO-A. It is concluded that monoamine oxidase-A inhibition at the beginning of the treatment does not predict clinical outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050100
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  • 2
    Electronic Resource
    Electronic Resource
    Comparative investigation of the effect of moclobemide and toloxatone on monoamine oxidase activity and psychometric performance in healthy subjects (1992)
    Springer
    Psychopharmacology 106 (1992), S. S68 
    Details
    ISSN: 1432-2072
    Keywords: Moclobemide ; Toloxatone ; Monoamine oxidase-A ; Psychometric performance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of moclobemide and toloxatone, two reversible monoamine oxidase-A inhibitors, on biochemical parameters that reflect monoamine metabolism and on psychomotor performance parameters were investigated in a study in 12 healthy volunteers. Treatments were given double-blind in a randomised, placebo-controlled cross-over design, with 1 week wash-out between the treatments. Drugs were given thrice daily in the following doses: moclobemide 150-150-150 mg and toloxatone 400-200-400 mg. All assessments were performed on day 8 under standardized conditions. There was no difference with regard to adverse events between moclobemide and toloxatone: both drugs induced a slight decrease in both supine and standing heart rate. Judged on the basis of the area under the curve, the two MAO-inhibitors reduced the plasma levels of DHPG and HVA, with more pronounced effects for moclobemide than for toloxatone. After moclobemide MAO-A inhibition was almost constant over 24 h, whereas the effect of toloxatone was short lasting after each dose. The same differences were reflected in plasma 5-HIAA concentrations and urinary excretion of 3-methoxytyramine and normetanephine. Neither of the compounds tested had any influence on the memory, vigilance, mood, or sleeping habits of the subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246239
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  • 3
    Electronic Resource
    Electronic Resource
    Evaluation and comparison of the interaction between alcohol and moclobemide or clomipramine in healthy subjects (1990)
    Springer
    Psychopharmacology 101 (1990), S. 40-45 
    Details
    ISSN: 1432-2072
    Keywords: Clomipramine ; Moclobemide ; Interaction with alcohol ; Psychometric performance ; Body sway ; Anticholinergic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The interaction of clomipramine and moclobemide with alcohol was compared in a double blind parallel groups study in 24 healthy volunteers. Moclobemide was given at the highest recommended therapeutic dose (200 mg t.i.d.) and clomipramine in a subtherapeutic dose (25 mg b.i.d.) because of its poor tolerance in healthy subjects. Psychometric evaluations were performed during a placebo run-in phase; after a 5-day treatment period; assessments were made before, and again 1 h and 4 h after alcohol ingestion. Alcohol doses were pre-determined for each subject in order to produce a blood alcohol concentration of 0.6 g/l 1 h after alcohol intake and this individual alcohol dose was given on test days. The day before alcohol intake tests for autonomic functions were made to assess the anticholinergic effects of the drugs. Alcohol significantly increased body sway, decreased critical flicker fusion frequency, prolonged choice reaction time, impaired copying skills, impaired memory and increased the subjective feelings of satisfaction and tension. Drugs increased the effect of alcohol on body sway and this was essentially due to clomipramine. Clomipramine both without and with alcohol increased body sway, prolonged choice reaction time more than did moclobemide. Clomipramine seemed to diminish alcohol-induced memory impairment in one of the memory tests used. Subjects taking clomipramine had significantly more adverse effects after alcohol ingestion than did subjects of the moclobemide group. In contrast to moclobemide, clomipramine produced a moderate but significant drop in standing systolic blood pressure and a clear inhibition of salivary excretion. It may be concluded that no important psychometric differences occurred between moclobemide and clomipramine with respect to their interaction with alcohol but moclobemide did not show anticholinergic properties and produced fewer adverse effects than clomipramine in interaction with alcohol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245787
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  • 4
    Electronic Resource
    Electronic Resource
    New electrophysical properties of polymer films and composites (1984)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 6 (1984), S. 239-243 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The abrupt decrease of electric resistance of thin polymer dielectric films and metal-polymer compositions has been observed in the course of their uniaxial compression. At pressures exceeding the critical one the conductivity of some metal-polymer compositions has been found to be as high as that for such metals as titanium. The dependences of specimen resistance on thickness, temperature and uniaxial pressure strongly support a new mechanism fo polymer dielectric conductivity based on the pressure induced injection of current carriers from a metal to the dielectric conduction band.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1984.020061984118
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  • 5
    Electronic Resource
    Electronic Resource
    Synthese neuer pseudoleiterpolymere mit 7H-benzimidazo[2,1-a]benzo[d,e]isochinolin-7-on-3,11-diyl-einheiten in der hauptkette (1982)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 183 (1982), S. 1615-1622 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A series of novel semi-ladder polymers containing 7H-benzimidazo[2,1-a]benzo[d,e]isoquinolin-7-on-3,11-diyl units in the chain was prepared by one-step high temperature solution polycondensation of 4,4′-oxy-,4,4′-carbonyl-, and 4,4′-sulfonyldi-1,8-naphthalenedicarboxylic anhydride (1a-c) with 2,2′-diamino-4,4′-oxydianiline (2) or 2,2′-diamino-4,4′-hexafluoroisopropylidenedianiline (4). The similarity of the IR and UV spectra of the polymers and the model compounds 7a-c confirms the presence of the benzimidazobenzoisoquinolinone rings in the polymer chain. All the resulting polymers have excellent thermal stability both in argon and in air. The polymers prepared from 4 are soluble in 1-methyl-2-pyrrolidone and phenol/1,1,2,2-tetrachloroethane.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1982.021830703
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  • 6
    Electronic Resource
    Electronic Resource
    Electrochemical and chemical syntheses and doping of [poly(2,2′-dithienyl)-5,5′-diylvinylene] (1987)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 188 (1987), S. 1425-1430 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The electroconductive polymer poly[(2,2′-dithienyl)-5,5′-diylvinylene] (1) was prepared by both electrochemical and chemical methods starting from trans-di(2-thienyl)ethylene (2). The electrochemically prepared material showed electrical conductivities of up to 40 Ω-1 · cm-1; the neutral, chemically prepared polymer was droped with iodine or arsenic pentafluoride but the conductivities were low. The experimental procedures are described and an interpretation of the results is given.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1987.021880618
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  • 7
    Electronic Resource
    Electronic Resource
    Electrochemical polymerization of 1H,7H-pyrrolo[2′,3′:4,5]-thieno[3,2-b]pyrrole and 4H-dithieno[3,2-b;2′,3′-d]pyrrole (1992)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 193 (1992), S. 399-409 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Electrochemical polymerization of 1H,7H-pyrrolo[2′,3′:4,5]thieno[3,2-b]pyrrole and 4H-dithieno[3,2-b;2′,3′-d]pyrrole in CH3CN + 0,1 M p-toluenesulfonate and tetraethylammonium perchlorate, respectively, yields polymers with a conductivity of ca. 5 S/cm. Electrochemistry and elemental analysis indicate the presence of 0,6-0,7 anions per monomeric unit, while spectroelectrochemistry agrees with a polypyrrole structure for polypyrrolothienopyrrole and a polythiophene structure for polydithienopyrrole. The redox cycle for polypyrrolothienopyrrole (at -0,53 V vs. Ag/Ag+) is close to that of polypyrrole, while that of polydithienopyrrole (at 0,0 V) is intermediate between those of polythiophene and polypyrrole. N-Alkylsubstituted dithienopyrroles produce soluble polymers with higher conductivity (40 S/cm) and the lowest band-gap (1,7 eV) ever reported for a polythiophene-like polymer.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1992.021930212
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  • 8
    Electronic Resource
    Electronic Resource
    Methyl labeling as a tool for investigating the regiochemistry of the electrochemical oxidative polymerization of 1H,8H-pyrrolo[3,2-g]indole (1990)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 191 (1990), S. 1497-1511 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The preparation of the three isomeric dimethyl derivatives 4-6 of 1 H,8H-pyrrolo[3,2-g]indole (1), substituted at the nitrogen atoms or in the positions α and β to them, respectively, is described. These products were synthesized for investigating the regiochemistry of the electrochemical oxidative polymerization of the parent compound 1. Anodic coupling in acetonitrile of the dimethyl derivatives 4-6 produces polymeric films which are reversibly oxidized with a charge exchange of 0,5 electrons per repeating unit. For 5 and 6, coupling occurs in the free positions of the pyrrole rings, yielding a non-conjugated and poorly conducting (5 · 10-6 Ω-1 · cm-1) polymer and a conjugated and conducting (1 Ω-1 · cm-1) polymer, respectively. The N-substituted isomer 4 couples in the α-positions and the resulting polymer shows a decrease in conductivity (10-2 Ω-1 · cm-1) relative to poly(1), analogous to that of poly(N-methylpyrrole) relative to polypyrrole. Further comparisons of conductivity data and behaviour of the methyl substituted derivatives of 1 allow to conclude that the unsubstituted polymer couples in the position α to the nitrogen atom.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1990.021910703
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  • 9
    Electronic Resource
    Electronic Resource
    Conducting polymers from anodic coupling of some N,N′-bridged 2,2′-bipyrrolyl monomers (1993)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 194 (1993), S. 1137-1147 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Anodic coupling in CH3CN + 0,1 M tetraethylammonium perchlorate of some 2,2′-bipyrrolyl monomers bridged by X groups at the N,N′-positions (X = —CH=CH— (1), o-C6H4 (2) —CH2— (3), —(CH2)2— (4) and —(CH2)3— (5)) produces conducting, α-coupled polypyrroles (from IR spectroscopy), containing 0,25-0,30 counteranions per pyrrole ring (from elemental analysis). The in-situ conductivity spans from values commonly found for N-substituted polypyrroles (4 ċ 10-3 S/cm for 5) to unusually high values (2,5 S/cm for 4). A linear correlation between redox potentials and log of conductivities of the polymers evidences the influence of the polymer electronic properties of charge transport.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1993.021940409
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  • 10
    Electronic Resource
    Electronic Resource
    Synthesis of polyureas by polycondensation of diamines with active derivatives of carbonic acid (1993)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 194 (1993), S. 3209-3228 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: New polycondensation reactions of active diphenyl carbonates and diphenyl carbamate with diamines were developed for the synthesis of high-molecular-weight polyureas. The kinetics and mechanism of carbonic acid active esters aminolysis model reactions were studied. Possible side reactions including nucleophilic substitution reaction were investigated as well. It is shown that novel methods advantageously distinguish from traditional methods of polyureas synthesis by low tendency to side reactions and facilitate the synthesis of linear polyureas and copolyureas. It is found that N,N′-bis(trimethylsilylated) diamines and salts of diamines as monomers can be successfully used in these reactions. Bioanalogous polymers promising for biomedical application  -  polyureas based on L-lysine  -  were synthesized using novel polycondensation reactions.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1993.021941201
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