Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Myocardial β-adrenergic receptor signaling in vivo: insights from transgenic mice (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 489-495 
    Details
    ISSN: 1432-1440
    Keywords: β-Adrenergic receptor ; β-Adrenergic receptor kinase ; G protein-coupled receptor kinase ; Transgenic mice ; Myocardial contractility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Heart failure is a problem of increasing importance in cardiovascular medicine. An important characteristic of heart failure is reduced agonist-stimulated adenylyl cyclase activity (receptor desensitization) due to both diminished receptor number (receptor downregulation) and impaired receptor function (receptor uncoupling). These changes in the §-adrenergic receptor (§ AR) system may in part account for some of the abnormalities of contractile function in this disease. Myocardial contraction is closely regulated by G protein coupled β-adrenergic receptors through the action of the second messenger cAMP. The β-adrenergic receptors themselves are regulated by a set of specific kinases, termed the G protein-coupled receptor kinases. The study of this complex system in vivo has recently been advanced by the development of transgenic and gene targeted (“knock out”) mouse models. Combining transgenic technology with sophisticated physiological measurements of cardiac hemodynamics is an extremely powerful strategy to study the regulation of myocardial contractility in the normal and failing heart.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00204974
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Myocardial β-adrenergic receptor signaling in vivo: insights from transgenic mice (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 489-495 
    Details
    ISSN: 1432-1440
    Keywords: Key words β-Adrenergic receptor ; β-Adrenergic receptor kinase ; G protein-coupled receptor kinase ; Transgenic mice ; Myocardial contractility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Heart failure is a problem of increasing importance in cardiovascular medicine. An important characteristic of heart failure is reduced agonist-stimulated adenylyl cyclase activity (receptor desensitization) due to both diminished receptor number (receptor downregulation) and impaired receptor function (receptor uncoupling). These changes in the §-adrenergic receptor (§-AR) system may in part account for some of the abnormalities of contractile function in this disease. Myocardial contraction is closely regulated by G protein coupled β-adrenergic receptors through the action of the second messenger cAMP. The β-adrenergic receptors themselves are regulated by a set of specific kinases, termed the G-protein-coupled receptor kinases. The study of this complex system in vivo has recently been advanced by the development of transgenic and gene targeted (”knockout”) mouse models. Combining transgenic technology with sophisticated physiological measurements of cardiac hemodynamics is an extremely powerful strategy to study the regulation of myocardial contractility in the normal and failing heart.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050051
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Mikroanalytische Aufgaben in Metallkunde und Metallurgie (1952)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 64 (1952), S. 187-195 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Microanalytical Problems in Metallography and MetallurgyMicroanalysis has become increasingly important in metallographic analyses during recent years. This paper shows the particular problems with reference to the investigation of the structure of iron and steel. It has been possible to determine important new information concerning carbide and oxide occlusions, as well as those of nitrides, sulphides and intermetallic compounds. Particular attention is paid to the problems arising in taking the samples.
    Notes: Die Mikroanalyse hat in den letzten Jahren für die metallkundliche Analyse sehr an Bedeutung gewonnen. Es wird hier gezeigt, welche Aufgaben ihr besonders bei der Gefügeforschung an Stahl und Eisen gestellt werden. Es ist gelungen, wesentliche neue Erkenntnisse über Carbide und oxydische Einschlüsse und solche von Nitriden, Sulfiden und intermetallischen Verbindungen zu erhalten. Besondere Sorgfalt wird den bei den Probenahmen auftretenden Problemen gewidmet.
    Additional Material: 20 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19520640704
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Fortschritte in der MikrochemieBeitrag I dieser Reihe: Roth, „Quantitative organische Mikroanalyse“ s. diese Ztschr. 53, 44 [1940].. II. Mikroanalytische Prüfverfahren zur Untersuchung von Eisen und StahlErscheint. gleichzeitig in Techn. Mitt. Krupp, Forschungsber. 3, 255 [1940].. Bestimmung von Kohlenstoff, Eisen, Silicium, Mangan, Phosphor, Schwefel, Aluminium, Stickstoff, Chrom, Nickel, Molybdän, Wolfram, Titan, Vanadin und ihre Trennung (1940)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 53 (1940), S. 537-549 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19400534702
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Spektrochemische Untersuchungen zur Mikroanalyse des Stahlgefüges (1956)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 68 (1956), S. 296-302 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Spektralanalytisch sind in isolierten Gefügebestandteilen des Stahls noch Spuren erfaßbar, die mikroanalytisch nicht bestimmt werden können. Spektralunempfindliche Elemente müssen zusätzlich mikroanalytisch erfaßt werden. Die sehr stark wechselnde Zusammensetzung der isolierten Teilchen erforderte ein leitprobenfreies spektralanalytisches Verfahren. Analysenmethoden für Einwaagen von 0,05 mg Substanz und eine dazugehörige Mikromanipulation wurden ausgearbeitet. Der Zeitaufwand ist gegenüber der Mikroanalyse gering. Die Verfahren sind nicht auf Stahl beschränkt, sondern können für viele analytische Arbeiten nützlich sein.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19560680807
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...