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  • General Chemistry  (6)
  • 1
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 94 (1982), S. 767-780 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Prostacyclin (PGI2), das zu den Prostanoiden gehört, senkt den Blutdruck und hemmt die Blutplättchenaggregation. Da Prostacyclin selbst sehr säurelabil ist, wurde in den letzten Jahren eine Vielzahl säurestabiler Analoga des Naturstoffes synthetisiert. Während verfeinerte analytische Verfahren die Hypothese widerlegt haben, Prostacyclin sei ein zirkulierendes Hormon, konnten in ersten klinischen Tests die in Tierversuchen gefundenen pharmakologischen Eigenschaften bestätigt werden; auch die klinische Prüfung von Prostacyclin-Analoga hat begonnen. In vitro stimulieren bewährte Herz-Kreislauf-Therapeutica die Prostacyclin-Synthese, doch konnte bisher nicht festgestellt werden, ob diese Effekte im erkrankten Organismus von therapeutischer Bedeutung sind. In diesem Beitrag wird eine Übersicht über die bisher synthetisierten Prostacyclin-Analoga gegeben, und es werden anhand mehrerer Beispiele die Syntheseprobleme geschildert; daneben werden auch Struktur-Wirkungsbeziehungen diskutiert.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 92 (1980), S. 850-855 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 21 (1982), S. 751-764 
    ISSN: 0570-0833
    Keywords: Carbacyclin ; Prostaglandins ; Prostacyclins ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The prostanoids continue to attract a great deal of attention, particularly in the pharmacological sector. Many of the numerous biological studies on prostaglandins deal with their cardiovascular effects. The pronounced antihypertensive and platelet aggregation-inhibiting properties of prostacyclin (PGI2) resulted in world-wide efforts to synthesize acid-stable analogues of the natural product. Whereas refined analytical procedures disproved the hypothesis that PGI2 is a circulating hormone, exploratory human trials with PGI2 confirmed the pharmacological findings obtained from animal experiments. Clinical studies of PGI2 analogues have been started. In vitro studies on isolated vessels revealed that potent cardiovascular drugs stimulate prostacyclin synthesis; however, it has not as yet been possible to demonstrate whether these effects are also of therapeutic significance. A survey of the PGI2 analogues synthesized so far is presented, and, with the aid of a few examples, the problems encountered during their synthesis are outlined; structure-activity relationships are also discussed.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 87 (1975), S. 143-151 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Prostaglandine sind lipidlösliche C20-Carbonsäuren mit einem fünfgliedrigen Ring, mehreren Sauerstoff-Funktionen und mindestens einer Doppelbindung. Sie kommen im tierischen Organismus vor, wo sie u. a. die glatte Muskulatur anregen. In den letzten 10 Jahren hat man mehr über das Vorkommen, die Biosynthese, den Metabolismus und die pharmakologischen Eigenschaften von Prostaglandinen gelernt. Analytische Verfahren zu ihrer Bestimmung und Synthesen für die Naturprodukte und deren künstliche Analogen wurden entwickelt. In diesem Fortschrittsbericht wird versucht darzulegen, warum diese Ergebnisse die pharmazeutische Forschung außerordentlich stimulieren.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 14 (1975), S. 337-344 
    ISSN: 0570-0833
    Keywords: Prostaglandins ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The prostaglandins are lipid-soluble C20-carboxylic acids containing a five-membered ring, several oxygen function, and at least one double bond. They are found in animal organisms where they stimulate, inter alia, the smooth muscle. In the last decade more has been learned about the occurrence, biosynthesis, metabolism and pharmacological properties of the prostaglandins. Analytical methods for their determination, and syntheses for the naturally occurring prostglandins and their synthetic analogs have been developed. In this report, an attempt is made to show why new knowledge has dramatically stimulated pharmaceutical research in this field.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 19 (1980), S. 819-820 
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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