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Role of octreotide in the treatment of external pancreatic pure fistulas: a single-institution prospective experience (2000)

Bassi, C. ; Falconi, M. ; Salvia, R. ; [et al.]

Springer

Langenbeck's archives of surgery 385 (2000), S. 10-13

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ISSN: 1435-2451

Keywords: Key words External pancreatic fistulas ; Octreotide ; Pancreatic cancer ; Pancreatic surgery ; Pancreatitis

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Introduction: Octreotide was studied in the treatment of pure external pancreatic fistulas. Methods: Eighteen cases (12 males, 6 females) were prospectively observed. Six patients (four after radical surgery for periampullary cancer, one endocrine tumor enucleation and one pancreojejunostomy in chronic pancreatitis) were treated as outpatients with octreotide alone because of low basal fistula output (mean±SD: 96.6±27.4 cc/24 h). Twelve (five radical surgery for cancer, five surgery for severe pancreatitis, one enucleation and one pancreojejunostomy) were treated as inpatients with octreotide plus total parenteral nutrition because of the high output (mean±SD: 448.4±248.2 cc/24 h). Results: Ten of the 12 high-output fistulas healed in 27.8±27.7 days, whereas all low-output fistulas healed in 12.1±6.6 days. Conclusion: Octreotide appears useful in the treatment of external pancreatic fistulas. For optimal results to be achieved, there must be no local infection and no mechanical or anatomical obstacles to the free flow of juice.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004230050003

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III. Yeast sequencing reports. Nucleotide sequence of 9·2 kb left of CRY1 on yeast chromosome III from strain ab972: Evidence for a ty insertion and functional analysis of open reading frame YCR28 (1992)

Carbone, M. L. Agostoni ; Panzeri, L. ; Falconi, M. Muzi ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Yeast 8 (1992), S. 805-812

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ISSN: 0749-503X

Keywords: Chromosome III ; Ty insertion ; gene disruption ; Life and Medical Sciences ; Genetics

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology

Notes: We report the 9210 bp sequence from a segment of yeat chromosome III cloned from strain AB972 in λPM3270. Analysis of this sequence and its comparison with the one derived from the corresponding segment of strain XJ24-24A revealed that the AB972 region contains a duplication of about 2 kb and a Ty element, which are not found in XJ24-24A and cause a quite significant rearrangement of the whole region. We performed analysis of YCR28, the largest open reading frame we found in both AB972 and XJ24-24A. YCR28 encodes a putative protein of 512 amino acids with some similarities to yeast allontoate permease. Its disruption does not cause any detectable phenotype on rich medium or on allantoate medium, while we observed a strain-dependent effect on senstivity to amino acid balance and to 3-aminotriazole, when cells were grown in synthetic medium.

Additional Material: 7 Ill.