ISSN:
1434-4726
Keywords:
Cochlea
;
Field stimulation
;
Vascular endothelium
;
Vasorelaxation
;
Glibenclamide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Rabbit aortic rings relaxed with an increase in cyclic guanosine monophosphate and cyclic adenosine monophosphate content in response to exposure to organ fluid of isolated cochleas of the guinea pig following field stimulation (50 Hz, 80 V, 0.2 ms). Relaxations were blocked by 30 μMN G-nitro-l-arginine methyl ester added to the vessel rings. This inhibitory effect was reversed by 3 MMl-arginine. Removal of the vascular endothelium also blocked the relaxation response. Glibenclamide attenuated vasorelaxation in a concentration-dependent manner. We conclude that cochlear nerve stimulation induces an endothelium-dependent vasorelaxation involving activation of adenosine triphosphate-sensitive potassium channels.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02439710
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