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  • 1
    Electronic Resource
    Electronic Resource
    Epstein-Barr virus infection after kidney transplantation (1998)
    Springer
    Transplant international 11 (1998), S. S119 
    Details
    ISSN: 1432-2277
    Keywords: Key words Epstein-Barr virus ; Kidney transplantation ; Infection ; Rejection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Besides the well-known association of Epstein-Barr virus (EBV) and lymphomas developing posttransplantation, there are only a few data concerning the prevalence of EBV antibodies (abs) in organ donors and recipients, the posttransplant development of antibody titer in the recipient population, the extent of EBV-IgM seroconversion, and the clinical and laboratory signs associated with infection. Therefore, in a retrospective analysis, we evaluated the data of 119 organ donors and 215 kidney graft recipients who received their kidney allografts between 1993 and 1995. A total of 665 sera were quantitatively tested by means of immunofluorescence assay for EBV abs against capsid (CA; IgM, IgG), early (IgG), and nuclear (IgG) antigens. Recipient sera were obtained for testing before kidney transplantation (KTx) and at post-KTx days 32, 67, and 649 (mean values). Pre-KTx all organ donors and 98.65 % of the recipients were EBV-CA-IgG positive, only in two cases was there a D+/R− (donor/recipient) combination leading to primary EBV infection. In comparison with the organ donors, in kidney graft recipients the pre-KTx IgG antibody titers (geometric mean) against EBV-CA were significantly elevated (1 : 428 vs 1 : 574; U-test). Post-KTx, EBV-CA-IgM seroconversion was observed in 29.5 % (52 out of 176) of first graft recipients and in 47.8 % (11 out of 23) of regrafted patients up to the last follow-up day 649. In 219 out of these 52 recipients, IgM abs again cytomegalovirus (CMV) could also be detected; the other 23 did not develop CMV-IgM abs. The most frequently associated clinical signs were fever (74 %), elevated aminotransferases (57 %), and deterioration of graft function (26 %). In the EBV-IgM+/CMV-IgM+ group there were significantly more rejection therapies than in the EBV-IgM+/CMV-IgM− group. With respect to the severity of EBV infections, 68 % were asymptomatic or mild, 27 % moderate, and 4 % (only 1) severe. Thus, besides the post-KTx CMV monitoring, EBV monitoring should also belong to the follow-up checks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050442
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  • 2
    Electronic Resource
    Electronic Resource
    Identification and chromosomal localization of the monkey retrotransposon in Musa sp. (2000)
    Springer
    Molecular genetics and genomics 263 (2000), S. 908-915 
    Details
    ISSN: 1617-4623
    Keywords: Key wordsSkippy ; Nucleolar organizer region (NOR) ; Somaclonal variation ; Repetitive sequence ; In situ hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Retroelements are ubiquitous features of eukaryotic genomes, often accounting for a substantial fraction of their total DNA content. One major group of retroelements, which includes the gypsy and copia-like elements, is distinguished by the presence of long terminal repeats (LTRs). We have identified and partially characterized a sequence from banana (Musa acuminata cv. Grand Nain) which shows significant homology to gypsy-like LTR retroelements from other species. The element, named monkey, shows a high degree of homology to the reverse transcriptase, RNase H and integrase genes of retroelements from plants, fungi and yeast. However, several stop codons are present in the major ORF of this element, suggesting that this copy of monkey, if functional, is non-autonomous. Southern analysis indicated that monkey is present in both the A and B genomes of Musa, and that it is found in 200–500 copies per haploid genome in cv. Grand Nain. Chromosomal localization by fluorescent in-situ hybridization indicates that copies of monkey are concentrated in the nucleolar organizer regions and colocalize with rRNA genes. Other copies of monkey appear to be dispersed throughout the genome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380000265
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  • 3
    Electronic Resource
    Electronic Resource
    Die Phagocytoseaktivität von permanenten Fibroblasten (Monocyten), Rattenalveolarmakrophagen und menschlichen Entzündungsmakrophagen unter der Wirkung von Glucocorticoiden (1967)
    Springer
    Clinical and experimental medicine 144 (1967), S. 335-352 
    Details
    ISSN: 1591-9528
    Keywords: Glucocorticoides ; phagocytosis ; macrophages ; fibroblastes ; dust exposition ; Glucocorticoide ; Phagocytose ; Makrophagen ; Fibroblasten ; Staubexposition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Glucocorticoide hemmen die Phagocytoseaktivität von permanenten Fibroblasten und Makrophagen in vitro. In der Kultur gezüchtete Monocyten gewöhnten sich bei einer Corticoiddauerbehandlung an das veränderte Milieu, ihre anfänglich gehemmte Phagocytoseaktivität nahm wieder zu. Makrophagen aus Rattenlungen sowie menschliche Entzündungsmakrophagen zeigten nach Corticoidbehandlung eine deutliche Abnahme ihrer Phagocytoseaktivität, die bei den Rattenmakrophagen von der Dauer der Behandlung und der Dosis abhängig war. Bei Bestaubung von corticoidbehandelten Ratten konnte ebenfalls eine von der Behandlungsdauer abhängige Abnahme der Phagocytoseaktivität im Alveolarraum beobachtet werden. Bei Kurzbehandlung zeigte sich eine bimodale Wirkung des applizierten Glucocorticoids durch gesteigerte Makrophagenemigration in den Alveolarraum.
    Notes: Summary Glucocorticoides inhibit the phagocytosis activity of permanent fibroblasts and macrophages in vitro. Monocytes raised in culture become accustomed to the changed medium during a continuous corticoide treatment; their initially inhibited phagocytosis activity increased again. Macrophages from rat lungs as well as human inflammation macrophages showed after corticoide treatment a marked decrease of their phagocytosis activity dependent, in case of rat macrophages on the duration of treatment and dose. During dusting of rats treated with corticoides, there could also be observed a decrease of the phagocytosis activity in the alveolar region dependent on the duration of treatment. In case of a short treatment there was a bimodal effect of the applied glucocorticoides showed by increased macrophage emigration into the alveolar region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02043239
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    Paper (German National Licenses)
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