ISSN:
1439-6327
Keywords:
Hyperglycaemia
;
He[atic glucose production
;
Insulin action
;
Glucose turnover
;
Glucose-free fatty acid interaction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effect of hyperglycaemia on hepatic glucose production (R a ) was investigated in nine healthy men using sequential clamp protocols during somatostatin infusion and euglycaemia (0–150 min), at plasma glucose levels of 165 mg · dl−1 (9.2 mM, 150–270 min) and during insulin infusion (1.0 mU · kg−1 · min−1, 270–360 min) in study 1 or during hypo-insulinaemia and plasma glucose levels of 220 mg · dl−1 (12.2 mM; 270–390 min) in study 2. Somatostatin decreased R a and glucose disposal rate (R d ) but increased plasma free fatty acids (FFA) and lipid oxidation during euglycaemia. Increasing plasma glucose to 165 mg · dl−1 (9.2 mM) and hypo-insulinaemia increased R d , but no suppressive effects on R a , plasma FFA and lipid oxidation were observed. By contrast hyperinsulinaemia (study 1), as well as a further increase in plasma glucose (study 2), both decreased R a . However, more pronounced hyperglycaemia increased insulin secretion despite somatostatin resulting in a fall in plasma FFA and lipid oxidation. Our data questions the accepted dogma that hyperglycaemia inhibits R a independently of insulin action.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00379399
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