ISSN:
1432-069X
Keywords:
Glucose-6-phosphate dehydrogenase
;
Dehydroepiandrosterone
;
Mononuclear leukocytes
;
Psoriasis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The aim of the study was to determine a biochemical basis for the augmented oxidative metabolism found in mononuclear leukocytes (MNL) of patients with active psoriasis. Dehydroepiandrosterone (DHEA) is known to inhibit glucose-6-phosphate dehydrogenase (G-6-PDH). We determined the activity of G-6-PDH as well as the penetration and metabolism of DHEA — diminished plasma concentrations of which have been found in psoriatics previously — in 16 patients with active psoriasis and 16 controls. MNL in patients with psoriasis possessed 52% more (p〈0.05) G-6-PDH activity, based on cell number, and 34% more (p〈0.05) activity, based on soluble protein. No difference in DHEA penetration and metabolism in MNL was found between psoriatics and controls, in contrast with previous findings of reduced penetration and increased reduction in erythrocytes of psoriatics. We conclude that the enhanced G-6-PDH activity in MNL of patients with active psoriasis is not due to altered DHEA penetration or metabolism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00418169
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