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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 236 (1989), S. 445-447 
    ISSN: 1432-1459
    Keywords: Amyotrophic lateral sclerosis ; Branched chain amino acids ; Glutamate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty-two patients affected by amyotrophic lateral sclerosis (ALS) were included in a controlled, open therapeutic trial with branched chain amino acids (BCAA). Patients with bulbar muscle involvement were evaluated separately. No statistically significant differences were found in the clinical outcome between the patients treated and the control groups. Blood l-glutamate levels measured in eight patients were normal. The failure of BCAA in the treatment of the patients could be due to different disorders with unpredictable outcome included under the diagnosis of ALS.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1590-3478
    Keywords: ALS ; MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Abbiamo considerato le risonanze nucleari magnetiche eseguite in 16 di un gruppo più ampio di pazienti con sclerosi laterale amiotrofica. Anomalie di segnale lungo i fasci piramidali erano osservabili in 11 pazienti ed erano più frequenti in coloro i quali presentavano una maggiore compromissione del primo motoneurone. Non vi era correlazione con la durata né con la severità della malattia. Il nostro studio suggerisce che le alterazioni di segnale mostrate dalla MRI lungo i fasci piramidali sono di frequente riscontronella ALS e possono riflettere la gravità della degenerazione dei fasci piramidali.
    Notes: Abstract Magnetic resonance imaging (MRI) studies of the brain were reviewed in 16 patients with amyotrophic lateral sclerosis (ALS), representative of a large and homogeneously studied series, 11 of whom showed signal abnormalities along the pyramidal tracts. These were more frequent in patients with more severe upper motor neuron signs but did not correlate with disease severity. Our study suggests that MRI signal abnormalities along the pyramidal tracts are common in ALS and may reflect the severity of pyramidal tract degeneration.
    Type of Medium: Electronic Resource
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