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  • 1
    Electronic Resource
    Electronic Resource
    Influence of human cytomegalovirus on immune reconstitution after bone marrow transplantation (1992)
    Springer
    Annals of hematology 64 (1992), S. A140 
    Details
    ISSN: 1432-0584
    Keywords: Cytomegalovirus infection ; Bone marrow transplantation ; Graft-versus-host disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary HCMV infection diagnosed by the highly sensitive polymerase chain reaction (PCR) technology in blood, urine and skin biopsies of patients after bone marrow transplantation (BMT) correlated with the reconstitution of peripheral blood lymphocytes and dermal immunohistological alterations to evaluate the interaction of viral infection with the recovery of the immune system, as well as with the induction or aggravation of graftversus-host disease (GVHD). In a prospective study 73% of 63 patients showed viremia at a median time of 25 days after BMT. Only 44% of these cases that also presented with a higher frequency of acute GVHD symptoms developed HCMB disease later on. In the skin, similar immunohistological alternations, as well as frequent primary local HCMV infection before the development of cutaneous signs of GVHD, was found, suggesting the direct involvement of anti-HCMV immune responses in the induction of GVHD-associated organ lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715368
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  • 2
    Electronic Resource
    Electronic Resource
    Immunohistological skin alterations in allogeneic bone marrow transplantation (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 675-688 
    Details
    ISSN: 1432-1440
    Keywords: Immunohistology ; Skin alterations ; Graft-versus-host disease ; Bone marrow transplantation ; Langerhans cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Skin biopsies of 26 patients with leukemia and seven patients with aplastic anemia were investigated before and at different stages after allogeneic bone marrow transplantation (BMT) to establish the immunological criteria which distinguish skin alterations during normal reconstitution from dermal lesions mediated by graft-versushost disease (GvHD). Of the 33 patients studied 27 presented with clinically diagnosed acute and/or chronic GvHD, one patient died of bone marrow rejection. Immunohistological analysis of the respective skin biopsies with selected monoclonal antibodies against human leukocyte antigens (HLA) and differentiation antigens of the lympho-hematopoietic cells revealed low dermal mononuclear cell counts with phenotypically normal constituents in five cases with uncomplicated reconstitution post-grafting. In contrast, increased dermal cellular infiltrates predominantly consisting of Lyt 3+, OKT 8+ T-lymphocytes, as well as of a large number of Ia-like (immune response associated = HLA-D) determinant+ monocytes/macrophages were observed in all patients with active acute/chronic GvH reactivity. As sign of activation simultaneous expression of HLA-D region products was also found on a subset of the invading OKT 8+ T-lymphocytes. Progression of GvHD was associated with additional surface staining of keratinocytes for Ia-like determinants. Loss of Ia-like determinant+, OKT 6+ dentritic epithelial cells in all leukemic patients, as well as in patients with aplastic anemia with or without GvHD suggested damage of Langerhans cells due to the previous radiotherapy and/or specific immunological destruction. In patients with fatal outcome of GvHD prolonged reduction of these dentritic epithelial cells seemed to be indicative of impaired immune reconstitution or bone marrow dysfunction. Thus immunopathological features of skin GvHR may enable early recognition and prognostic evaluation of this disease possibly allowing more effective therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716464
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Mechanische Eigenschaften von kaltgezogenem und gegossenem Titan Grad 2 (1998)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 29 (1998), S. 714-719 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Mechanical properties of cold-drawn and cast Grade 2 TitaniumThe static and dynamic properties of Grade 2 Titanium for dental applications are investigated. The typical casting procedures used in dental laboratories lead to a drastic deterioration of the mechanical properties compared to wrought material. This deterioration is caused by changes in microstructure and surface roughness. The experimental results are used to determine opportunities for improvements and their limits.
    Notes: In dieser Arbeit werden die statischen und dynamischen Eigenschaften von in der Zahntechnik verwendetem Titan Grad 2 untersucht. Es zeigt sich, daß die in zahntechnischen Laboratorien üblichen Herstellungsprozesse und Bearbeitungsschritte bei gegossenem Titan eine erhebliche Verschlechterung der Eigenschaften gegenüber kommerziell erhältlichen Ti-Halbzeugen bewirken. Diese Verschlechterung läßt sich auf Änderungen im Gefüge und der Oberflächenrauhigkeit zurückführen. Aus den Untersuchungsergebnissen werden Möglichkeiten und Grenzen für die Optimierung des Herstellungsprozesses für Zahnersatz aus Titan Grad 2 abgeleitet.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19980291205
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    60. Optische Chemo- und Biosensoren für die Bioverfahrenstechnik (1993)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 65 (1993), S. 1086-1086 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330650962
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  • 5
    Electronic Resource
    Electronic Resource
    Über die sulfonierung von polystyrol mit der anlagerungs-verbindung von schwefeltrioxyd an dioxan (1956)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 18 (1956), S. 139-150 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: The sulfonation of polystyrene with concentrated sulfuric acid, oleum or chlorosulfonic acid yields products which swell but are insoluble. On the other hand, soluble products are obtained by sulfonation with the addition compound of sulfur trioxide with dioxane.The preparation, purification and analysis of such polystyrene sulfonic acids and their salts are described. The degree of sulfonation can be varied within wide limits. Products with one sulfonic acid group to about ten phenyl groups are soluble in alcohols and other polar solvents while higher sulfonated products are soluble in water.
    Notes: Die Sulfonierung des Polystyrols mit konzentrierter Schwefelsäure oder Oleum oder Chlorsulfonsäure führt zu unlöslichen, nur quellbaren Polystyrolsulfonsäuren. Im Gegensatz dazu erhält man mit der Additionsverbindung von Schwefeltrioxyd an Dioxan lösliche Produkte.Die Herstellung, Reinigung und Analyse von derartigen Polystyrolsulfonsäuren und ihrer Salze wird beschrieben. Der Sulfonierungsgrad kann in weiten Grenzen variiert werden. Produkte mit einer Sulfonsäuregruppe pro ca. zehn Phenylreste sind in gewissen Alkoholen und anderen polaren Lösungsmitteln löslich, höher sulfonierte in Wasser.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1956.020180113
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    Paper (German National Licenses)
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