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  • Graft-versus-host disease  (1)
  • T-helper lymphocytes  (1)
  • intracytoplasmic sperm injection (ICSI)  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Cyclosporin a: Pharmacologic activity on the immune system and effects in clinical organ transplantation (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 1053-1062 
    Details
    ISSN: 1432-1440
    Keywords: Immunosuppression ; Delayed-type hypersensitivity ; Cell-mediated cytolysis ; T-helper lymphocytes ; Graft-versus-host disease ; Clinical transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The recently discovered fungal metabolite cyclosporin A (CsA) is a potent immunosuppressant that is effective in preventing transplantation rejection due to allografts and even xenografts. Due to its influence on the biological activity of T-helper lymphocytes CsA's mechanism of action includes inhibition of cell-mediated cytolysis and delayed-type hypersensitivity (DTH) reaction. In addition to studies of the molecular mechanism of action, data on the pharmacokinetics of CsA are given. CsA does not cause anti-mitotic and/or cytotoxic effects. The side effects of the agent are relatively mild and appear to be reversible. CsA has been successfully used clinically in renal, bonemarrow, heart, heart-lung, liver, and pancreas transplantation. The application of the compound in organ transplantation appears to be superior to conventional immunosuppressive therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01496465
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Perinatal Outcome of Pregnancies After Assisted Reproduction: A Case–Control Study (1997)
    Springer
    Journal of assisted reproduction and genetics 14 (1997), S. 575-580 
    Details
    ISSN: 1573-7330
    Keywords: in vitro fertilization (IVF) ; intracytoplasmic sperm injection (ICSI) ; pregnancy ; perinatal outcome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: A matched case–control study of all pregnancies obtained after either IVF or ICSI was conducted to investigate the perinatal outcome. Methods: Three hundred eleven singleton and 115 twin pregnancies obtained after assisted reproduction were studied. Controls were selected from a regional register and were matched for maternal age, parity, singleton or twin pregnancy, and date of delivery. Results: No significant difference was observed for gestational age at delivery, birth weight, incidence of congenital anomalies, and incidence of perinatal mortality between ART (singleton and twin) pregnancies and spontaneous controls. ART twin pregnancies showed a higher incidence of preterm deliveries than control pregnancies (52 vs 42%; P 〈 0.05) and needed more neonatal intensive care (47 vs 26%; P 〈 0.05). Conclusions: From this case–control study it is concluded that the perinatal outcome of ART singleton pregnancies is not different from that in matched controls. ART twin pregnancies showed a higher incidence of preterm deliveries than control pregnancies and needed more neonatal intensive care.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022576500894
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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