ISSN:
1432-1440
Keywords:
Immunosuppression
;
Delayed-type hypersensitivity
;
Cell-mediated cytolysis
;
T-helper lymphocytes
;
Graft-versus-host disease
;
Clinical transplantation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The recently discovered fungal metabolite cyclosporin A (CsA) is a potent immunosuppressant that is effective in preventing transplantation rejection due to allografts and even xenografts. Due to its influence on the biological activity of T-helper lymphocytes CsA's mechanism of action includes inhibition of cell-mediated cytolysis and delayed-type hypersensitivity (DTH) reaction. In addition to studies of the molecular mechanism of action, data on the pharmacokinetics of CsA are given. CsA does not cause anti-mitotic and/or cytotoxic effects. The side effects of the agent are relatively mild and appear to be reversible. CsA has been successfully used clinically in renal, bonemarrow, heart, heart-lung, liver, and pancreas transplantation. The application of the compound in organ transplantation appears to be superior to conventional immunosuppressive therapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01496465
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