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  • Granulocyte colony-stimulating factor  (1)
  • Walking robot  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Improvement of neutropenia and neutrophil dysfunction by granulocyte colony-stimulating factor in a patient with glycogen storage disease type Ib (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 18-20 
    Details
    ISSN: 1432-1076
    Keywords: Glycogen storage disease type Ib ; Neutropenia ; Granulocyte colony-stimulating factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patients with glycogen storage disease type Ib (GSD Ib) suffer from recurrent bacterial infections due to neutropenia and neutrophil dysfunction. To improve the quality of life in a 9-year-old boy with GSD Ib, we subeutaneously administered recombinant human granulocyte colony-stimulating factor (G-CSF). Daily injections of 100 μg/m2 of G-CSF significantly increased absolute neutrophil counts and augmented neutrophil mobility. The patient was then treated with 70 and 100 μg/m2 of G-CSF daily and twice-weekly. The treatment maintained absolute neutrophil counts at significantly higher levels than those without treatment for 22 months and markedly decreased the frequency of infections and the necessity for hospitalisation. No adverse effects were observed during treatment. These findings indicate that daily and twice-weekly treatment with G-CSF of long duration are safe and effective for patients with GSD Ib. G-CSF may be a useful therapeutic agent in patients with neutrophilic impairment as a consequence of a metabolic disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02072510
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Evolving neural controllers that elicit nontrivial behaviors using a developmental process (1999)
    Springer
    Artificial life and robotics 3 (1999), S. 106-111 
    Details
    ISSN: 1614-7456
    Keywords: Evolutionary robotics ; Developmental process ; Nontrivial behaviors ; Canalization ; Walking robot
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Recently, evolutionary robotics (ER) has been attracting a lot of attention in the field of robotics artificial life and so on. ER approaches are expected to provide feasible methods to design controllers for autonomous mobile robots with less human intervention. However, most of the conventional studies in ER have been aiming at obtaining very simple (trivial) behaviors such as obstacle avoiding, wall following, and target approaching. To make the ER approach more fruitful, we should pay close attention to obtaining nontrivial behaviors. Based on these considerations, in this paper we propose a method for obtaining nontrivial behaviors using a developmental process with a carefully arranged grafting method. To verify the validity, we apply our idea to the construction of neural controllers that can cope with rough terrain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02481256
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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