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  • Growth hormone  (1)
  • Immunoelectron microscopy  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Mammosomatotroph adenoma of the pituitary associated with gigantism and hyperprolactinemia. A morphological study including immunoelectron microscopy (1986)
    Springer
    Acta neuropathologica 71 (1986), S. 76-82 
    Details
    ISSN: 1432-0533
    Keywords: Gigantism ; Hyperprolactinemia ; Immunoelectron microscopy ; Mammosomatotroph ; Pituitary adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 29-year old giantess with growth hormone excess and hyperprolactinemia underwent transsphenoidal surgery to remove her pituitary tumor. Electron microscopy revealed a mammosomatotroph adenoma composed of one cell type. Immunoelectron microscopy, using the immunogold technique, demonstrated predominantly growth hormone or prolactin or a varying mixture of both growth hormone and prolactin in the adenoma cells. The presence of growth hormone and prolactin was found not only in the cytoplasm of the same adenoma cells but also in the same secretory granules. In the nontumorous adenohypophysis, somatotrophs and lactotrophs showed ultrastructural signs of hyperactivity. This finding is in contrast with the presence of suppressed somatotrophs and lactotrophs seen in nontumorous portions of adult pituitaries harboring growth hormone or prolactin-secreting adenomas. Our morphological study reinforces the view that growth hormone-producing pituitary tumors, originating in childhood, are different from those of the adult gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687965
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Growth hormone-producing pituitary adenoma with giant secretory granules (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 239-241 
    Details
    ISSN: 1432-0533
    Keywords: Acromegaly ; Electron microscopy ; Growth hormone ; Pituitary adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Unusually large, oval and pleomorphic secretory granules were noted by electron microscopy in an acidophilic adenoma of the pituitary. The tumor, which was removed by surgery from a 42-year-old woman with elevated blood growth hormone levels and the clinical features of acromegaly, was found to contain growth hormone by the immunoperoxidase technique. This ultrastructural abnormality of secretory granules was not reported so far and was not seen among the 58 cases of growth hormone-producing adenomas investigated in our laboratory. The present case clearly shows that the cytogenesis and cellular composition of pituitary adenomas cannot be determined by solely examining the size and shape of secretory granules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690852
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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