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  • 1
    Electronic Resource
    Electronic Resource
    Polyglucosan bodies in sural nerve biopsies (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 554-557 
    Details
    ISSN: 1432-0533
    Keywords: Polyglucosan bodies ; Sural nerve biopsy ; Lafora's disease ; Ageing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence of polyglucosan bodies in sural nerves collected over a 16-year period was studied in relation to age, sex, presence of polyneuropathy, and concomitant presence of central nervous system disorder. Polyglucosan bodies have been seen in only one patient without a polyneuropathy. This patient was suffering from Lafora's disease. In all other sural nerves positive for polyglucosan bodies a polyneuropathy was present. Within this group the prevalence of polyglucosan bodies was positively correlated with age, and if a central nervous system disorder was associated, this prevalence was more distinct. With semiquantitative measurements of the surface of polyglucosan bodies a significant correlation was found between age and percentage of large bodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294618
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of human growth hormone therapy on skinfold thickness in growth hormone-deficient children (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 588-592 
    Details
    ISSN: 1432-1076
    Keywords: Growth hormone ; Somatropin ; Skinfold thickness ; Body composition ; Growth hormone deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Skinfold thickness (ST) was measured in 43 children with various forms of growth hormone (GH) deficiency during the first year of GH therapy. The average (and SEM) initial ST, expressed as standard deviation score (SDS) was 1.17 (0.25) for subscapular, 0.63 (0.18) for triceps, and 0.40 (0.21) for biceps ST. During therapy the average decrease is 1 SD. Children in the pubertal age group and those with partial GH deficiency showed smaller decreases. A larger decrease of triceps ST was associated with lower GH and insulin peaks, and lower age, bone age and initial weight-for-height. Some correlations between ST decrease and growth response in the first year were significant, but still too low to allow of reliable predictions. The same was true for other clinical parameters. These data indicate that a chronic lack of GH leads to unequal fat distribution, possibly due to different sensitivities to GH in the trunk and extremities. The variability of ST responses to GH therapy limits clinical applications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442469
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of light deprivation on the electro retinogram of the guinea pig (1970)
    Springer
    Pflügers Archiv 318 (1970), S. 1-6 
    Details
    ISSN: 1432-2013
    Keywords: Lichtentzug ; Elektroretinogramm ; Light Deprivation ; Electro Retinogram
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The b-wave in the ERG of guinea pigs born and reared in darkness for three months is considerably smaller than that in animals of the same age reared under normal circumstances. Exposure to room illumination for ten days greatly restores the ERG. The ERG in four days old light deprived animals is normally developed. A three months light deprivation period causes a relatively small effect in normally raised adult animals. From these experiments it is concluded that the initial ERG development in the guinea pig is not affected by light deprivation. However, once developed the ERG in new born animals is more vulnerable to prolonged light deprivation than that in adult ones.
    Notes: Zusammenfassung Die b-Welle im ERG von Meerschweinchen, die in Dunkelheit geboren und 3 Monate lang aufgezogen wurden, ist merklich kleiner als bei Tieren gleichen Alters, die unter normalen Umständen aufgezogen wurden. Eine 10 Tage dauernde Einwirkung von Raumlicht stellt das ERG weitgehend wieder her. Das ERG von 4 Tage alten lichtentzogenen Tieren ist normal entwickelt. Ein 3 Monate langer Lichtentzug hat relativ geringe Wirkung auf normal aufgezogene erwachsene Tiere. Aus diesen Versuchen wird geschlossen, daß die ursprüngliche ERG-Entwicklung beim Meerschweinchen durch Lichtentzug nicht gestört wird. Hingegen ist das bereits entwickelte ERG von neugeborenen Tieren gegenüber dauerndem Lichtentzug anfälliger als bei erwachsenen Tieren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588538
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    Paper (German National Licenses)
    Fulltext
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