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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of cyclic nucleotides in guinea pig lip (1980)
    Springer
    Archives of dermatological research 269 (1980), S. 233-237 
    Details
    ISSN: 1432-069X
    Keywords: Cyclic nucleotides ; Localization ; Guinea pig lip ; Cyclische Nukleotide ; Lokalisation ; Meerschweinchenlippe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die celluläre Lokalisation von cAMP und cGMP in der Meerschweinchenlippe wurde mit einer indirekten Immunofluorescenztechnik untersucht. Es konnte gezeigt werden, daß cAMP in Zellmembranen und in cytoplasmatischen Elementen mit grober und granulärer intranukleärer Fluorescenz verteilt ist, während cGMP in nukleären Lagen einschließlich nukleärer Membranen sowie Zellmembranen und Cytoplasmata vorkommt. Im basalen Anteil war die Fluorescenz von cAMP und cGMP in Cytoplasma und Zellmembranen schwächer als im oberen Anteil.
    Notes: Summary The cellular localization of cAMP and cGMP in the guinea pig lip was investigated with an indirect immunofluorescence technique. cAMP was distributed both in cell membranes and cytoplasmic elements with coarse and granular intranuclear fluorescence, while cGMP was localized in nuclear sites including nuclear membranes as well as cell membranes and cytoplasm. In the basal portion, both cAMP and cGMP fluorescence was weaker in cytoplasm and cell membranes than seen in the upper portion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406416
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ultraviolet B radiation downregulates inducible nitric oxide synthase expression induced by interferon-γ or tumor necrosis factor-α in murine keratinocyte Pam 212 cells (2000)
    Springer
    Archives of dermatological research 292 (2000), S. 312-319 
    Details
    ISSN: 1432-069X
    Keywords: Key words Ultraviolet B radiation ; Nitric oxide ; Nitric oxide synthase ; Murine keratinocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Ultraviolet radiation causes inflammation characterized by erythema and swelling, but also exhibits antiinflammatory effects which have led to the use of ultraviolet B radiation (UVBR) and psoralen plus ultraviolet A (PUVA) in the treatment of psoriasis, chronic severe atopic dermatitis and uremic pruritus. In inflammatory dermatoses, a pathogenic role of nitric oxide (NO) derived from inducible nitric oxide synthase (iNOS) has been suggested. To elucidate how UVBR regulates iNOS expression in skin under inflammatory conditions, we investigated the effect of UVBR on NO production and iNOS expression in cultured murine keratinocyte Pam 212 cells stimulated with interferon-Á (IFN-Á) or tumor necrosis factor-· (TNF-·). Low doses of UVBR significantly suppressed IFN-Á- or TNF-·-induced NO production. UVBR also downregulated IFN-Á- or TNF-·-induced iNOS expression at both the mRNA level and the protein level. These findings suggest the possibility that the downregulatory effect of UVBR on IFN-Á- or TNF-·-induced iNOS expression may, in part, explain the antiinflammatory and therapeutic properties of UVBR in inflammatory dermatoses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030000124
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    Paper (German National Licenses)
    Fulltext
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