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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 269 (1980), S. 233-237 
    ISSN: 1432-069X
    Keywords: Cyclic nucleotides ; Localization ; Guinea pig lip ; Cyclische Nukleotide ; Lokalisation ; Meerschweinchenlippe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die celluläre Lokalisation von cAMP und cGMP in der Meerschweinchenlippe wurde mit einer indirekten Immunofluorescenztechnik untersucht. Es konnte gezeigt werden, daß cAMP in Zellmembranen und in cytoplasmatischen Elementen mit grober und granulärer intranukleärer Fluorescenz verteilt ist, während cGMP in nukleären Lagen einschließlich nukleärer Membranen sowie Zellmembranen und Cytoplasmata vorkommt. Im basalen Anteil war die Fluorescenz von cAMP und cGMP in Cytoplasma und Zellmembranen schwächer als im oberen Anteil.
    Notes: Summary The cellular localization of cAMP and cGMP in the guinea pig lip was investigated with an indirect immunofluorescence technique. cAMP was distributed both in cell membranes and cytoplasmic elements with coarse and granular intranuclear fluorescence, while cGMP was localized in nuclear sites including nuclear membranes as well as cell membranes and cytoplasm. In the basal portion, both cAMP and cGMP fluorescence was weaker in cytoplasm and cell membranes than seen in the upper portion.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-069X
    Keywords: Leukocytoclastic vasculitis ; Oxygen intermediates ; Polymorphonuclear leukocyte ; Vascular injury ; Immune complexes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of sera from patients with untreated leukocytoclastic vasculitis was investigated on the generation of oxygen intermediates by normal polymorphonuclear leukocytes. Sera from untreated patients induced increased hydroxyl radical generation, which is one of the most potent oxidants capable of causing tissue damage. It is suggested that vascular injury may be mediated in part by enhanced production of hydroxyl radical by polymorphonuclear leukocytes. Circulating immune complexes in the sera of the patients are considered to be one of the factors responsible for enhanced generation of hydroxyl radical.
    Type of Medium: Electronic Resource
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