ISSN:
1432-0533
Keywords:
Experimental Allergic Encephalomyelitis (EAE)
;
Vascular permeability
;
Evans bluealbumin
;
Horseradish peroxidase
;
Guinea pigs
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The vascular permeability in the nervous system to Evans blue-albumin and horseradish peroxidase was studied in chronic relapsing EAE in strain 13 and Hartley guinea pigs. The disease was induced by single sensitization of immature animals and was characterized clinically by remissions and relapses. Recent and old demyelinating plaques in the spinal cord were present. These showed an increased permeability to the protein tracers. The blood-brain barrier in these plaques are therefore disturbed and also in this respect the condition is similar to the multiple sclerosis lesions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00691696
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