ISSN:
1432-1912
Keywords:
Key words ATP release
;
Angiotensin II
;
Losartan
;
AT1-receptor
;
Cultured smooth muscle cells
;
Guinea-pig taenia coli
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Effects of angiotensin II on ATP release were evaluated in segments and cultured smooth muscle cells from the guinea-pig taenia coli. In the segments, angiotensin II (0.3–3 μM) elicited release of ATP which was blocked by losartan and SC-52458, non-peptide angiotensin II type-1 receptor (AT1)-antagonists, but not by PD-123319, an AT2-antagonist. In superfused cultured cells, 10 μM angiotensin II likewise elicited release of ATP. Again the response was blocked by losartan and SC-52458 but not by PD-123319. These findings suggest that angiotensin II releases ATP from the smooth muscles by activation of angiotensin II-, presumably AT1-, receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00166908
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