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  • 1
    Electronic Resource
    Electronic Resource
    Pathological Changes in the Formation of Helicobacter pylori-Induced Gastric Lesions in Mongolian Gerbils (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 754-765 
    Details
    ISSN: 1573-2568
    Keywords: H. PYLORI ; MONGOLIAN GERBIL ; GASTRIC MUCOSAL LESIONS ; INFLAMMATION ; MYELOPEROXIDASE ; NEUTROPHIL CHEMOTAXIS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined pathological changes in theformation of Helicobacter pylori-induced gastric lesionsin Mongorian gerbils. H. pylori (NCTC11637) was orallyadministered once to the animals and was detected in the gastric mucosa of all gerbils given thebacteria. The number of viable H. pylori increasedduring the initial two weeks and thereafter reached aplateau level. The initial pathological changes were found at one week, ie, edema/congestion and awhite viscous substance only in the antrum. At twoweeks, superficial damage appeared in the antrum,although inflammatory cell infiltration had notoccurred. Gastritis with lymphoid follicles was observedin the antrum and fundus from three weeks. At fourweeks, mucosal lesions were detected as a fewhemorrhagic spots in the fundus adjacent to the antrum.In the control animals, however, no pathologicalchanges were observed even at four weeks. In the gastricmucosa infected with H. pylori , myeloperoxidaseactivity was negligible at two weeks, but was extremely elevated at four weeks. Similarly, neutrophilchemotactic activity was only slightly increased at twoweeks, but was markedly elevated at four weeks. Theseresults indicate that H. pylori infection induces initial pathological changes only in theantrum, but mucosal lesions occur in the fundus adjacentto the antrum. Furthermore, it is demonstrated that theinitial superficial damage is generated by factors other than chemokines and neutrophil-associatedfactors, although mucosal inflammation may contribute tothe subsequent formation of lesions andulcers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018861930068
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Healing of Helicobacter pylori -Induced Gastric Ulcers in Mongolian Gerbils (Combined Treatment with Omeprazole and Clarithromycin) (1999)
    Springer
    Digestive diseases and sciences 44 (1999), S. 257-265 
    Details
    ISSN: 1573-2568
    Keywords: OMEPRAZOLE ; CLARITHROMYCIN ; COMBINED TREATMENT ; H. PYLORI-INDUCED ULCERS ; MONGOLIAN GERBILS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Helicobacter pylori can colonize the stomachs ofMongolian gerbils and subsequently induce penetratingulcers five months later. Using this gerbil model, theeffects of both combined treatment with omeprazole and clarithromycin, as well as treatment witheach drug separately, on the healing of H.pylori-induced gastric ulcers, and the effects of thecessation of the drug treatment on healed ulcers wereexamined. Beginning five months after H. pylori(NCTC11637) inoculation, omeprazole (four weeks),clarithromycin (two weeks), their combination, or thevehicle was orally administered once daily. These drugs,in combination or separately, markedly enhancedulcer healing and lowered the increased myeloperoxidase(MPO) activity. While omeprazole had no effect on viableH. pylori, clarithromycin and the drug combination significantly reduced viable H. pylori. Thedegree of bacterial eradication was much higher in thecase of the drug combination compared to clarithromycinalone. Four months after cessation of the treatment, visible ulcers, hypertrophic gastritis andincreased MPO activity were found in the control animals(all H. pylori-positive). Nonetheless, only one of theeight gerbils subjected to the drug combination developed a small ulcer, although nohypertrophic gastritis was exhibited. It is concludedthat: (1) the gerbil model of H. pylori infection isuseful for the study of ulcer healing; (2) combinedtreatment with omeprazole and clarithromycin enhances theulcer healing in infected gerbils; and (3) healed ulcersdo not relapse, despite cessation of the drugtreatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026685929992
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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