ISSN:
1573-2568
Keywords:
HEPATOCELLULAR CARCINOMA
;
HEPATITIS B VIRUS
;
POLYMERASE CHAIN REACTION
;
TRANSACTIVATOR
;
HBSAG
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Hepatitis B virus is associated with humanhepatocellular carcinoma. We performed polymerase chainreaction for the X, C, S, and preS2/S regions of theviral genome in 23 hepatitis B surface antigen-negative hepatocellular carcinomas and adjacent liver.Hepatitis B viral genomes were detected in 17 of 23tumors and adjacent tissues (73.9%). Among recognizedtransactivators, the X gene was present in 16 (69.6%) cases of hepatocellular carcinoma, but preS2/Swas detected in only 7 (30.4%). Hepatitis B virus C andS regions were detected in 3 (13.0%) and 9 (39.1%)hepatocellular carcinomas, respectively. Serologic study revealed antibodies to hepatitis Bsurface antigen, hepatitis B core antigen, and hepatitisB e antigen in 14 patients; among these, X-gene DNA wasdetected in 12 of 14 tumors (85.7%). The X gene was also detected in 4 of 9 tumors ofseronegative patients. The X gene, present in manyhepatocellular carcinomas, may promote hepatocellularcarcinoma in hepatitis B surface antigen-negativepatients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1018814700915
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