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  • 1
    Electronic Resource
    Electronic Resource
    Bioavailability of indomethacin from a modified release system containing indomethacin as the lysine salt (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 85-87 
    Details
    ISSN: 1432-1041
    Keywords: indomethacin ; lysine salt ; controlled release formulation ; plasma concentration ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The bioavailability of a new controlled release formulation of indomethacin lysine salt in tablets was tested in 6 healthy humans against a conventional indomethacin lysinate formulation in capsules. Both contained 100 mg of the drug, i.e. 70 mg indomethacin. Peak plasma levels were lower and more lasting and the AUC was higher with the new controlled release formulation. The latter on average produced active plasma levels for 12 h, and so it can be recommended for twice daily administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609963
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Coexpression of HER-2/neu and p53 is associated with a shorter disease-free survival in node-positive breast cancer patients (1994)
    Springer
    Journal of cancer research and clinical oncology 120 (1994), S. 737-742 
    Details
    ISSN: 1432-1335
    Keywords: HER-2/neu ; p53 ; Breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Breast cancer tissue was examined for overexpression of HER-2/neu and p53 oncogene proteins. Samples from 105 breast cancer patients were investigated by Western-blot analysis and their relationship to other established markers and clinical outcome was examined. In 21.0% of the cases HER-2/neu was overexpressed, and in 46.7% the p53 protein level was increased. Expression of these two oncogene products was closely correlated. Overexpression of both oncogenes was associated with larger tumour size and negative hormone receptor. The percentage of HER-2/neu and p53 overexpression was higher in node-positive patients, although statistical evaluation was not significant. While overexpression of HER-2/neu as well as p53 in node-positive patients was associated insignificantly with shorter disease-free survival, a significant difference could be documented when the disease-free survival of patients with overexpression of both oncogene proteins was compared to that of patients with no overexpression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01194273
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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