ISSN:
0952-3499
Keywords:
Reverse transcriptase
;
Pharmacophore
;
Nucleoside analog inhibitors
;
HIV-1
;
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
An ‘active analog’ approach to receptor mapping was used to identify a pharmacophore for a set of thymidine nucleoside analog inhibitors of HIV-1 reverse transcriptase. The preliminary results indicate that the O2, O4′, and O5′ atoms are capable of adopting a unique pharmacophoric pattern which may be the key to their recognition by reverse transcriptase.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jmr.300070309
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