ISSN:
1572-994X
Keywords:
SIVmac
;
HIV-1
;
HIV-2
;
Gag
;
capsid
;
gene therapy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Mutations were introduced into a genomic region encoding the C-terminal portion of Gag capsid protein of pathogenic simian immunodeficiency virus (SIVmac239). All the mutants generated were defective for virion production and were non-infectious for monkey cells. They all efficiently suppressed the replication of wild type SIVmac in monkey cells. These results were in good agreement with those obtained for human immunodeficiency virus type 1, showing the importance of SIV/monkey model system for studies on Gag.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008001000878
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