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  • HL-60 cell line  (1)
  • SRE sequence affinity  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Human platelets contain a novel 47 kDa thiol-oxidase having affinity for genomic sterol-regulatory sequence (1998)
    Springer
    Molecular and cellular biochemistry 178 (1998), S. 383-385 
    Details
    ISSN: 1573-4919
    Keywords: SRE sequence affinity ; 47 kDa factor ; thiol-oxidase activity ; platelets ; lymphocytes ; CML patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The present study provides evidence to support that human platelets possess a 47 kDa dual functional molecule having thiol-oxidase activity as well as high affinity for the SRE sequence in the human genome. On the basis of these as well as earlier results, we propose that Receptor 'Ck' dependent regulation of this dual functional 47 kDa molecule may provide a mechanism for the maintenance of cellular cholesterol homeostasis. Further, this mechanism nay also explain the molecular basis of cholesterol-feedback lesion observed under premalignant conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006853001631
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27) (1999)
    Springer
    Molecular and cellular biochemistry 200 (1999), S. 183-186 
    Details
    ISSN: 1573-4919
    Keywords: mevalonate pathway ; CDK inhibitors ; Receptor-Ck expression ; TPA ; HL-60 cell line
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The present study was addressed to understand the interrelationship between Receptor-Ck induction-activation coupling; isoprenoids (derived from mevalonate pathway) and cyclin-dependent kinase inhibitors. The results reported here unambiguously reveal that isoprenoids regulate the expression of genes coding for CDK inhibited p16 and p27. Further, Receptor-Ck dependent signalling, known to control the mevalonate pathway, had a direct effect upon the p27 gene expression. Based upon these studies coupled with our earlier findings we propose that Receptor-Ck has an important role in the regulation of cell cycle machinery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006981614054
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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