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  • 1
    Electronic Resource
    Electronic Resource
    The effect of insulin and catecholamines on the activities of 3-hydroxy-3-methyl glutaryl coenzyme A reductase and acyl-coenzyme A: cholesterol-o-acyltransferase in isolated rat hepatocytes (1986)
    Springer
    Diabetologia 29 (1986), S. 122-124 
    Details
    ISSN: 1432-0428
    Keywords: Insulin ; noradrenaline ; isoprenaline ; bicyclic cascade system ; HMG CoA reductase ; ACAT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study was concerned with the effect of insulin and catecholamines on the rate limiting enzymes of cholesterol metabolism in rat hepatocytes. Insulin was found to increase the activity of 3-hydroxy-3-methyl glutaryl coenzyme A reductase and to have no effect on the activity of acyl-coenzyme A: cholesterol-o-acyltransferase. Noradrenaline and isoprenaline increased the activities of both 3-hydroxy3-methyl glutaryl coenzyme A reductase and acyl-coenzyme A: cholesterol-o-acyltransferase. The effect of noradrenaline or isoprenaline in the presence of insulin was that of a lower stimulatory response on 3-hydroxy-3-methyl glutaryl coenzyme A reductase but comparable to that found with either catecholamine alone. The combination of either catecholamine with insulin had no effect on the activity of acyl-coenzyme A: cholesterol-o-acyltransferase. These observations suggest that the activities of 3-hydroxy-3-methyl glutaryl coenzyme A reductase and acyl-coenzyme A: cholesterol-o-acyltransferase are regulated independently by insulin in the presence or absence of catecholamines. By contrast, catecholamines appear to regulate both enzyme activities in a similar fashion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00456123
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The response of the antioxidant defense system in rat hepatocytes challenged with oxysterols is modified by Covi-ox (1998)
    Springer
    Cell biology and toxicology 14 (1998), S. 401-409 
    Details
    ISSN: 1573-6822
    Keywords: 7-ketocholesterol ; cholestane-3β,5α,6β-triol ; antioxidant enzymes ; hepatocytes ; tocopherol blend ; food additive
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Suspension cultures of isolated rat hepatocytes were used to investigate whether 7-ketocholesterol and cholestane-3β,5α,6β-triol exert oxidative stress in cells as manifested by increased lipid peroxidation and the induction of the antioxidant enzymes catalase, glutathione peroxidase and superoxide dismutase. The oxysterols were found to increase the levels of both superoxide dismutase and catalase and to have variable effects on glutathione peroxidase activity. Increased lipid peroxidation was not observed, indicating that the endogenous antioxidant defense system was capable of protecting against any oxidative stress that might otherwise by exerted by 7-ketocholesterol or cholestane-3β,5α,6β-triol. Covi-ox, a natural tocopherol blend reduced the effects of both oxysterols on the antioxidant enzymes. A concurrent reduction in the production of thiobarbituric acid-reactive substances in Covi-ox-treated cells is indirect evidence that reactive oxygen species were produced by oxysterols in hepatocyte suspension cultures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007595527176
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    Paper (German National Licenses)
    Fulltext
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