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  • 1
    Electronic Resource
    Electronic Resource
    Can Humans Metabolize Arsenic Compounds to Arsenobetaine? (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 11 (1997), S. 327-335 
    Details
    ISSN: 0268-2605
    Keywords: arsenic ; urine ; HPLC-ICP-MS ; arsenobetaine ; Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Arsenic compounds were determined in 21 urine samples collected from a male volunteer. The volunteer was exposed to arsenic through either consumption of codfish or inhalation of small amounts of (CH3)3As present in the laboratory air. The arsenic compounds in the urine were separated and quantified with an HPLC-ICP-MS system equipped with a hydraulic high-pressure nebulizer. This method has a determination limit of 0.5 μg As dm-3 urine. To eliminate the influence of the density of the urine, creatinine was determined and all concentrations of arsenic compounds were expressed in μg As g-1 creatinine. The concentrations of arsenite, arsenate and methylarsonic acid in the urine were not influenced by the consumption of seafood. Exposure to trimethylarsine doubled the concentration of arsenate and increased the concentration of methylarsonic acid drastically (0.5 to 5 μg As g-1 creatinine). The concentration of dimethylarsinic acid was elevated after the first consumption of fish (2.8 to 4.3 μg As g-1 creatinine), after the second consumption of fish (4.9 to 26.5 μg As g-1 creatinine) and after exposure to trimethyl- arsine (2.9 to 9.6 μg As g-1 creatinine). As expected, the concentration of arsenobetaine in the urine increased 30- to 50-fold after the first consumption of codfish. Surprisingly, the concentration of arsenobetaine also increased after exposure to trimethylarsine, from a background of approximately 1 μg As g-1 creatinine up to 33.1 μg As g-1 creatinine. Arsenobetaine was detected in all the urine samples investigated. The arsenobetaine in the urine not ascribable to consumed seafood could come from food items of terrestrial origin that - unknown to us - contain arsenobetaine. The possibility that the human body is capable of metabolizing trimethyl- arsine to arsenobetaine must be considered. © 1997 by John Wiley & Sons, Ltd.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 2
    Electronic Resource
    Electronic Resource
    Speciation and health risk considerations of arsenic in the edible mushroom Laccaria amethystina collected from contaminated and uncontaminated locations (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 12 (1998), S. 285-291 
    Details
    ISSN: 0268-2605
    Keywords: mushroom ; arsenic speciation ; HPLC-ICP-MS ; dimethylarsinic acid ; arsenobetaine ; trimethylarsine oxide ; toxicological evaluation ; soil contamination ; Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Samples of the edible mushroom Laccaria amethystina, which is known to accumulate arsenic, were collected from two uncontaminated beech forests and an arsenic-contaminated one in Denmark. The total arsenic concentration was 23 and 77 μg  As g-1 (dry weight) in the two uncontaminated samples and 1420 μg As g-1 in the contaminated sample. The arsenic species were liberated from the samples using focused microwave-assisted extraction, and were separated and detected by anion- and cation-exchange high-performance liquid chromatography with an inductively coupled plasma mass spectrometer as arsenic-selective detector. Dimethylarsinic acid accounted for 68-74%, methylarsonic acid for 0.3-2.9%, trimethylarsine oxide for 0.6-2.0% and arsenic acid for 0.1-6.1% of the total arsenic. The unextractable fraction of arsenic ranged between 15 and 32%. The results also showed that when growing in the highly arsenate-contaminated soil (500-800 μg As g-1) the mushrooms or their associated bacteria were able to biosynthesize dimethylarsinic acid from arsinic acid in the soil. Furthermore, arsenobetaine and trimethylarsine oxide were detected for the first time in Laccaria amethystina. Additionally, unidentified arsenic species were detected in the mushroom. The finding of arsenobetaine and trimethylarsine oxide in low amounts in the mushrooms showed that synthesis of this arsenical in nature is not restricted to marine biota. In order to minimize the toxicological risk of arsenic to humans it is recommended not to consume Laccaria amethystina mushrooms collected from the highly contaminated soil, because of a genotoxic effect of dimethylarsinic acid observed at high doses in animal experiments. © 1998 John Wiley & Sons, Ltd.No Abstract.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
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